Liu Qiuyu, Wang Yi, Huang Jin, Liu Xiangmei, Mao Congyang, Wang Chaofeng, Zheng Yufeng, Liu Hanpeng, Lai Khin Wee, Li Zhaoyang, Zhu Shengli, Jiang Hui, Cui Zhenduo, Wu Shuilin
School of Materials Science & Engineering, Biomedical Materials Engineering Research Center, Hubei Key Laboratory of Polymer Materials, Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials, State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei University, Wuhan 430062, China.
School of Health Science & Biomedical Engineering, Hebei University of Technology, Tianjin 300401, China.
ACS Nano. 2025 Apr 8;19(13):13341-13355. doi: 10.1021/acsnano.5c01112. Epub 2025 Mar 27.
Conventional periodontitis treatments can be superseded by sonodynamic therapy. In this study, a Zn(OH)F/CaF heterojunction was synthesized via a hydrothermal method, which exhibited good biocompatibility and antibacterial properties. The band gap decreased significantly after the formation of the heterojunction, thereby enhancing the internal electron transfer. In addition, after the bacteria contact with the material, the electrons of the electron transport chain turn to Zn(OH)F/CaF and affect its steady state. Ultimately, HO in an inflammatory environment was used to react with Zn(OH)F/CaF to facilitate electron transfer under the influence of ultrasound, ultimately enhancing the catalytic activity. Zn(OH)F/CaF exhibits significant antibacterial efficacy against and . Trace elements Ca and Zn can promote tissue repair and osteogenic differentiation, resulting in less bone destruction and intact gingival tissue after periodontitis treatment. This sonodynamic therapy provides a rapid antibacterial, effective, and deep therapeutic method for treating periodontitis.
传统的牙周炎治疗方法可能会被声动力疗法所取代。在本研究中，通过水热法合成了Zn(OH)F/CaF异质结，其具有良好的生物相容性和抗菌性能。异质结形成后，带隙显著降低，从而增强了内部电子转移。此外，细菌与材料接触后，电子传输链的电子转向Zn(OH)F/CaF并影响其稳态。最终，炎症环境中的羟基自由基与Zn(OH)F/CaF反应，在超声作用下促进电子转移，最终增强催化活性。Zn(OH)F/CaF对[具体细菌1]和[具体细菌2]表现出显著的抗菌效果。微量元素Ca和Zn可以促进组织修复和成骨分化，使牙周炎治疗后骨破坏减少，牙龈组织完整。这种声动力疗法为治疗牙周炎提供了一种快速抗菌、有效且深入的治疗方法。
