Zhu Rixin, Sun Dan, He Shun, Yin Jun, Xiao Wang, Yang Guang-Fu
National Key Laboratory of Green Pesticide, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan 430079, China.
The Center of Crop Nanobiotechnology, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan 430074, China.
ACS Appl Mater Interfaces. 2025 Apr 9;17(14):21796-21807. doi: 10.1021/acsami.5c00837. Epub 2025 Mar 27.
As the second most important fungal pathogen, () poses a serious threat to crop yields and agricultural safety. Pyraclostrobin (PYR), a broad-spectrum QoI fungicide, has been widely utilized since its launch in 2003. However, the inhibitory effects of both PYR technical and PYR formulations on are not outstanding. Even at a concentration of 50 μg/mL, the inhibition rates of by both PYR technical and PYR formulations remain below 85%. In this work, we prepared an acid-responsive Pickering emulsion encapsulating PYR (PYR@BTIB-PE), which completely inhibited at low concentrations (25 μg/mL) for the first time. The PYR@BTIB-PE achieved fragmentation and release within 4 min at pH 5, which was consistent with the pH around The PYR@BTIB-PE can rapidly release PYR when infected and increased the concentration of PYR around the , thereby enhancing the efficacy of PYR. In addition, the released organic solvent from PYR@BTIB-PE enhanced the passing property of the membrane, facilitating more PYR to enter the body of . The improvement of the membrane passing property and rapid response release of PYR@BTIB-PE worked together to achieve complete inhibition of . Furthermore, the flexible and amphiphilic structures of PYR@BTIB-PE increased its interaction with the leaf surface, completely suppressed droplet splashing, and promoted droplet spreading, thereby reducing pesticide loss and improving the utilization rate of the pesticide. This study presents an efficient and rapid strategy for inhibiting and is also expected to be extended to other antifungal preparations.
作为第二重要的真菌病原体，（）对作物产量和农业安全构成严重威胁。吡唑醚菌酯（PYR）是一种广谱QoI杀菌剂，自2003年推出以来已被广泛使用。然而，PYR原药和PYR制剂对（）的抑制效果并不突出。即使在50μg/mL的浓度下，PYR原药和PYR制剂对（）的抑制率仍低于85%。在这项工作中，我们制备了一种包封PYR的酸响应型Pickering乳液（PYR@BTIB-PE），它首次在低浓度（25μg/mL）下完全抑制了（）。PYR@BTIB-PE在pH 5时4分钟内实现破碎和释放，这与（）周围的pH值一致。当（）被感染时，PYR@BTIB-PE可以快速释放PYR，增加（）周围PYR的浓度，从而提高PYR的功效。此外，PYR@BTIB-PE释放的有机溶剂增强了（）细胞膜的通透性，促进更多的PYR进入（）体内。PYR@BTIB-PE细胞膜通透性的改善和快速响应释放共同作用，实现了对（）的完全抑制。此外，PYR@BTIB-PE的柔性两亲结构增加了其与叶表面的相互作用，完全抑制了液滴飞溅，并促进了液滴铺展，从而减少了农药损失，提高了农药利用率。本研究提出了一种高效快速的抑制（）的策略，也有望扩展到其他抗真菌制剂。
