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Lysophosphatidic acid signaling: Transmembrane modulators in the central nervous system.

作者信息

Polyzou Alexandra, Tsiouris Alexandros K, Labrakakis Charalampos, Eickholt Britta J, Leondaritis George

机构信息

Department of Pharmacology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece (Polyzou A, Tsiouris AK, Leondaritis G).

Department of Biological Applications and Technology, School of Health Sciences, University of Ioannina, Ioannina, Greece (Labrakakis C).

出版信息

Neural Regen Res. 2026 Mar 1;21(3):1104-1105. doi: 10.4103/NRR.NRR-D-24-01465. Epub 2025 Mar 25.

DOI:10.4103/NRR.NRR-D-24-01465
PMID:40145978
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12296401/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a31/12296401/1a1622ec4916/NRR-21-1104-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a31/12296401/1a1622ec4916/NRR-21-1104-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a31/12296401/1a1622ec4916/NRR-21-1104-g001.jpg

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本文引用的文献

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Cell type-specific and subcellular expression of phospholipid phosphatase-related proteins to modulate lyso-phosphatidic acid synaptic signaling in the developing and adult CNS.调节发育和成年中枢神经系统溶血磷脂酸突触信号的磷脂酶相关蛋白的细胞类型特异性和亚细胞表达。
J Neurochem. 2024 Sep;168(9):3050-3062. doi: 10.1111/jnc.16169. Epub 2024 Jul 12.
2
Lysophosphatidic acid, a simple phospholipid with myriad functions.溶血磷脂酸，一种具有多种功能的简单磷脂。
Pharmacol Ther. 2023 Jun;246:108421. doi: 10.1016/j.pharmthera.2023.108421. Epub 2023 Apr 18.
3
Autotaxin facilitates selective LPA receptor signaling.
自分泌运动因子促进选择性溶血磷脂酸受体信号传导。
Cell Chem Biol. 2023 Jan 19;30(1):69-84.e14. doi: 10.1016/j.chembiol.2022.12.006. Epub 2023 Jan 13.
4
Modes of action of lysophospholipids as endogenous activators of the TRPV4 ion channel.溶血磷脂作为TRPV4离子通道内源性激活剂的作用模式。
J Physiol. 2023 May;601(9):1655-1673. doi: 10.1113/JP284262. Epub 2023 Jan 31.
5
Plasma membrane phospholipid phosphatase-related proteins as pleiotropic regulators of neuron growth and excitability.质膜磷脂磷酸酶相关蛋白作为神经元生长和兴奋性的多效性调节因子。
Front Mol Neurosci. 2022 Sep 15;15:984655. doi: 10.3389/fnmol.2022.984655. eCollection 2022.
6
Lipid Phosphate Phosphatases and Cancer.脂质磷酸酶与癌症。
Biomolecules. 2020 Sep 2;10(9):1263. doi: 10.3390/biom10091263.
7
TRPV1: Structure, Endogenous Agonists, and Mechanisms.TRPV1：结构、内源性激动剂和作用机制。
Int J Mol Sci. 2020 May 12;21(10):3421. doi: 10.3390/ijms21103421.
8
Role of lysophosphatidic acid in ion channel function and disease.溶血磷脂酸在离子通道功能和疾病中的作用。
J Neurophysiol. 2018 Sep 1;120(3):1198-1211. doi: 10.1152/jn.00226.2018. Epub 2018 Jun 27.
9
Lysophosphatidic acid-induced itch is mediated by signalling of LPA receptor, phospholipase D and TRPA1/TRPV1.溶血磷脂酸诱导的瘙痒是由溶血磷脂酸受体、磷脂酶D和瞬时受体电位锚蛋白1/瞬时受体电位香草酸亚型1的信号传导介导的。
J Physiol. 2017 Apr 15;595(8):2681-2698. doi: 10.1113/JP273961. Epub 2017 Mar 22.
10
Precise Somatotopic Thalamocortical Axon Guidance Depends on LPA-Mediated PRG-2/Radixin Signaling.精确的躯体感觉定位丘脑皮质轴突导向依赖于LPA介导的PRG-2/根蛋白信号传导。
Neuron. 2016 Oct 5;92(1):126-142. doi: 10.1016/j.neuron.2016.08.035. Epub 2016 Sep 15.