Department of Biochemistry, University of Alberta, Edmonton, AB T6G 2S2, Canada.
Cancer Research Institute of Northern Alberta, University of Alberta, Edmonton, AB T6G 2E1, Canada.
Biomolecules. 2020 Sep 2;10(9):1263. doi: 10.3390/biom10091263.
Lipid phosphate phosphatases (LPPs) are a group of three enzymes (LPP1-3) that belong to a phospholipid phosphatase (PLPP) family. The LPPs dephosphorylate a wide spectrum of bioactive lipid phosphates, among which lysophosphatidate (LPA) and sphingosine 1-phosphate (S1P) are two important extracellular signaling molecules. The LPPs are integral membrane proteins, which are localized on plasma membranes and intracellular membranes, including the endoplasmic reticulum and Golgi network. LPPs regulate signaling transduction in cancer cells and demonstrate different effects in cancer progression through the breakdown of extracellular LPA and S1P and other intracellular substrates. This review is intended to summarize an up-to-date understanding about the functions of LPPs in cancers.
脂质磷酸酶（LPPs）是一组三种酶（LPP1-3），属于磷脂磷酸酶（PLPP）家族。LPPs 去磷酸化广泛的生物活性脂质磷酸酯，其中溶血磷脂酸（LPA）和鞘氨醇 1-磷酸（S1P）是两种重要的细胞外信号分子。LPPs 是整合膜蛋白，位于质膜和细胞内膜上，包括内质网和高尔基体网络。LPPs 通过分解细胞外 LPA 和 S1P 以及其他细胞内底物来调节癌细胞中的信号转导，并通过不同的方式影响癌症进展。这篇综述旨在总结 LPPs 在癌症中的作用的最新认识。
