Savchenko Viktoriia, Yu Xiaoqian Annie, Polz Martin F, Böttcher Thomas
Faculty of Chemistry, Institute for Biological Chemistry & Centre for Microbiology and Environmental Systems Science, Department of Microbiology and Ecosystems Science, University of Vienna Josef-Holaubek-Platz 2 (UZA II), 1090 Vienna, Austria.
Vienna Doctoral School in Chemistry (DoSChem), University of Vienna, Währinger Str. 42, 1090 Vienna, Austria.
ACS Chem Biol. 2025 Apr 18;20(4):960-966. doi: 10.1021/acschembio.5c00046. Epub 2025 Mar 27.
2-Alkyl-4(1)-quinolones play a key role in bacterial communication, regulating biofilm formation, and virulence. Their antimicrobial properties also support bacterial survival and interspecies competition in microbial communities. In addition to the human pathogen various species of and are known to produce 2-alkyl-4(1)-quinolones. However, the evolutionary relationships of their biosynthetic gene clusters remain largely unexplored. To address this, we investigated the phylogeny of 2-alkyl-4(1)-quinolone biosynthetic gene clusters, leading to the discovery of as a fourth genus capable of producing 2-alkyl-4(1)-quinolones, expanding our knowledge of the diversity of bacteria involved in quinolone-biosynthesis.
2-烷基-4(1)-喹诺酮在细菌通讯、调节生物膜形成和毒力方面发挥着关键作用。它们的抗菌特性也有助于细菌在微生物群落中的生存和种间竞争。除了人类病原体外，已知多种[具体物种1]和[具体物种2]会产生2-烷基-4(1)-喹诺酮。然而，它们生物合成基因簇的进化关系在很大程度上仍未被探索。为了解决这个问题，我们研究了2-烷基-4(1)-喹诺酮生物合成基因簇的系统发育，从而发现[具体属名]是能够产生2-烷基-4(1)-喹诺酮的第四个属，扩展了我们对参与喹诺酮生物合成的细菌多样性的认识。
