[Animal experiment studies on the hemodynamic effect of adrenaline following intravenous and endobronchial administration].

The objective of this study was to find a dosage of endobronchially administered epinephrine with haemodynamic effects comparable to those after intravenous injection and therefore useful in cardiopulmonary resuscitation without an intravenous line. We found that 100 micrograms/kg epinephrine given endobronchially was almost as effective as an intravenous dose of 10 micrograms/kg concerning onset (10 seconds after intravenous injection, 15 seconds after endobronchial instillation) and maximum drug effect but with a remarkable prolongation of drug action. The instillation of 250 micrograms/kg epinephrine produced no significant increase in haemodynamic response. It was concluded, that the endobronchial instillation of epinephrine--in adequate dosage--is very useful in CPR without an intravenous line.