Zhen Zhen, Guo Rui, Tan Bolin, Wang Ying, Shi Shuyan, Ye Yang, Che Xianwei
Centre for Cognition and Brain Disorders, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, China.
Centre for Cognition and Brain Disorders, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, China; Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
Clin Neurophysiol. 2025 May;173:173-180. doi: 10.1016/j.clinph.2025.03.020. Epub 2025 Mar 22.
This study sort to identify the continuous effects of repetitive transcranial magnetic stimulation (rTMS) over the dorsolateral prefrontal cortex (DLPFC-rTMS) on local and distributed brain activities.
In a double-blinded and sham-controlled design, 24 participants received either a real or sham DLPFC-rTMS session, with concurrent TMS-EEG being recorded at baseline, 5 and 60 min after stimulation.
DLPFC stimulation induced immediate cortical excitability in the frontal regions, while a continuous effect was identified in the parietal cortex for up to 60 min. Moreover, this pattern of cortical excitability effects was reliably identified across TMS-induced field potentials and oscillations.
Single-session DLPFC stimulation induced both immediate and continuous cortical excitability effects for at least 60 min. The continuous cortical excitability change. was most prominent over the parietal cortices.
These novel findings may inform the design of TMS treatment paradigms to optimise cortical excitability and potentially clinical efficacy.
本研究旨在确定重复经颅磁刺激（rTMS）作用于背外侧前额叶皮质（DLPFC-rTMS）对局部和分布式脑活动的持续影响。
在双盲和假刺激对照设计中，24名参与者接受了真实或假的DLPFC-rTMS治疗，同时在基线、刺激后5分钟和60分钟记录TMS-EEG。
DLPFC刺激在额叶区域诱发了即时皮质兴奋性，而在顶叶皮质中发现了长达60分钟的持续效应。此外，这种皮质兴奋性效应模式在TMS诱发的场电位和振荡中得到了可靠识别。
单次DLPFC刺激至少在60分钟内诱发了即时和持续的皮质兴奋性效应。皮质兴奋性的持续变化在顶叶皮质最为显著。
这些新发现可能为TMS治疗方案的设计提供参考，以优化皮质兴奋性并潜在提高临床疗效。
