Yin Xiaofei, Geng Xinrong, Li Wenjun, Che Tuanjie, Yan Libo, Yuan Biao, Qin Song
Research Institute of Marine Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Qingdao, Shandong 266112, China; Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai, Shandong 264003, China; Yantai Center of Technology Innovation for Coastal Zone Biological Resource Utilization, Yantai, Shandong, China.
Zhigong Biomedicine Co., Ltd, Yantai, Shandong 2640035, China; Yantai Center of Technology Innovation for Coastal Zone Biological Resource Utilization, Yantai, Shandong, China.
Int J Pharm. 2025 Apr 30;675:125502. doi: 10.1016/j.ijpharm.2025.125502. Epub 2025 Mar 25.
In recent years, the morbidity and death rate of patients with tumors have been continuously increasing. How to administer radiotherapy, chemotherapy, and other methods for reducing damage to normal tissue cells and accurately targeting the tumor is one of the key issues in solving the problem of cancer. Using nanocarriers is a feasible approach into targeted control on the release of medicine to increase patient compliance. Nowadays, many researchers are gradually focusing on the application of drug delivery systems with natural ingredients as carriers in tumor therapy. At the same time, natural active ingredients may have better biocompatibility and fewer side effects. Especially, a variety of polysaccharides from algae has exhibited antitumor activity, providing greater possibilities for their use as drug delivery carriers. To facilitate the advancement and clinical translation of algae-derived polysaccharides in medical applications, we summarized the structural features of a range of polysaccharides extracted from macroalgae, their physical properties suitable for use as carriers, and the ways they are utilized in delivering medicines in oncology therapy (particularly in combination with novel oncology therapies, such as immunotherapy and photothermal therapy).
近年来，肿瘤患者的发病率和死亡率持续上升。如何进行放疗、化疗等，以减少对正常组织细胞的损伤并精准靶向肿瘤，是解决癌症问题的关键之一。使用纳米载体是实现药物靶向控释以提高患者依从性的可行方法。如今，许多研究人员逐渐关注以天然成分作为载体的药物递送系统在肿瘤治疗中的应用。同时，天然活性成分可能具有更好的生物相容性和更少的副作用。特别是，多种藻类多糖已表现出抗肿瘤活性，为其作为药物递送载体的应用提供了更大的可能性。为推动藻类衍生多糖在医学应用中的进展和临床转化，我们总结了从大型藻类中提取的一系列多糖的结构特征、适合用作载体的物理性质，以及它们在肿瘤治疗中（特别是与免疫疗法和光热疗法等新型肿瘤疗法联合使用时）递送药物的方式。
