College of Chemistry, Jilin University, Changchun 130012, PR China.
College of Resources and Environment, Jilin Agricultural University, Changchun 130118, PR China.
Carbohydr Polym. 2022 Mar 1;279:119013. doi: 10.1016/j.carbpol.2021.119013. Epub 2021 Dec 15.
The unique natural advantages of polysaccharide materials have attracted attention in biomedical applications. The abundant modifiable functional groups on the polysaccharide materials surface can facilitate the synthesis of various multifunctional drug delivery carriers. Especially in tumor therapy, the designs of polysaccharide-based drug delivery carriers are diverse. Therefore, this review summarized several latest types of polysaccharide-based drug carriers designs, and focused on the latest design strategies and considerations of drug carriers with polysaccharides as the main structure. It is expected to provide some design ideas and inspiration for subsequent polysaccharide-based drug delivery systems.
多糖材料独特的天然优势在生物医药应用中引起了关注。多糖材料表面丰富的可修饰功能基团有利于合成各种多功能药物输送载体。特别是在肿瘤治疗方面，多糖基药物输送载体的设计多种多样。因此，本综述总结了几种最新类型的多糖基药物载体设计，并重点介绍了以多糖为主结构的药物载体的最新设计策略和考虑因素。希望为后续的多糖基药物输送系统提供一些设计思路和启示。
