Li Hong-Min, Zhang Xi-Ru, Liao Dan-Qing, Gao Jian, Qiu Cheng-Shen, Zhong Wen-Fang, Tang Xu-Lian, Chen Pei-Liang, Du Li-Ying, Yang Jin, Lai Shu-Min, Huang Qing-Mei, Wang Xiao-Meng, Song Wei-Qi, You Fang-Fei, Li Chuan, Shen Dong, Mao Chen, Li Zhi-Hao
Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China.
Microbiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Transl Psychiatry. 2025 Mar 27;15(1):100. doi: 10.1038/s41398-025-03314-6.
Sleep behaviours are potentially modifiable risk factors for infectious disease. However, little is known about the combined effects of multiple sleep factors on the risk of infections. We investigated the prospective associations of combined healthy sleep patterns with the risk of hospitalization for infection in 397,523 participants (mean (SD) age: 56.3 (8.1) years) from the UK Biobank. Healthy sleep patterns were defined by healthy sleep scores according to a combination of adequate sleep duration (7-8 h/day), early chronotype, no insomnia, and no excessive daytime sleepiness. During a median follow-up of 13.5 (interquartile range: 12.4-14.2) years, 60,377 cases of hospitalization for any infection were documented. A healthy sleep score was inversely associated with the risk of hospitalization for any infection and various infection subtypes in a dose-dependent manner (P for trend < 0.001). The associations between a one-point increment of healthy sleep score and hospitalization for infections ranged from a 9% lower risk for sepsis (HR = 0.91; 95% CI, 0.89-0.93) to a 20% lower risk for liver infection (HR = 0.80; 95% CI, 0.74-0.87). More than 10% of hospitalizations for any infection could have been prevented if all participants adhered to the four low-risk sleep behaviours. Adherence to a healthy sleep pattern was associated with a decreased risk of hospitalization for infections, especially for individuals <65 years of age and females (P for interaction < 0.00045). Our findings highlight the potential of sleep behaviour interventions for the primary prevention of infectious diseases.
睡眠行为是传染病潜在的可改变风险因素。然而，对于多种睡眠因素对感染风险的综合影响知之甚少。我们调查了英国生物银行中397523名参与者（平均（标准差）年龄：56.3（8.1）岁）的健康睡眠模式组合与感染住院风险之间的前瞻性关联。健康睡眠模式由健康睡眠评分定义，该评分基于充足的睡眠时间（7 - 8小时/天）、早起型、无失眠和无白天过度嗜睡的组合。在中位随访13.5年（四分位间距：12.4 - 14.2年）期间，记录了60377例因任何感染住院的病例。健康睡眠评分与任何感染及各种感染亚型的住院风险呈剂量依赖性负相关（趋势P<0.001）。健康睡眠评分每增加1分与感染住院之间的关联范围为，败血症风险降低9%（HR = 0.91；95%CI，0.89 - 0.93）至肝脏感染风险降低20%（HR = 0.80；95%CI，0.74 - 0.87）。如果所有参与者都坚持这四种低风险睡眠行为，超过10%的因任何感染住院的情况本可避免。坚持健康睡眠模式与感染住院风险降低相关，尤其是对于65岁以下的个体和女性（交互作用P<0.00045）。我们的研究结果凸显了睡眠行为干预在传染病一级预防中的潜力。
