Seetharaman Jayendra
Division of Pediatric Gastroenterology and Hepatology, Department of Pediatrics, Christian Medical College, Vellore, Tamil Nadu, India.
Indian J Pediatr. 2025 May;92(5):526-534. doi: 10.1007/s12098-025-05469-y. Epub 2025 Mar 28.
Recurrent abdominal pain (RAP) is defined as the presence of at least 3 episodes of abdominal pain for 3 mo duration, including both organic and functional etiology. Up to 95% of the causes of RAP are due to functional abdominal pain disorders (FAPD). Peptic ulcer disease, cholelithiasis, chronic pancreatitis, abdominal tuberculosis, inflammatory bowel diseases (IBD), parasitic infection, and urinary tract infection (UTI) are prominent organic causes of RAP. The published data from developed countries reported pooled prevalence of FAPD in children is 13.5%, in which irritable bowel syndrome (IBS) is the most common sub-type. The evaluation includes history taking regarding pain characteristics, associated symptoms, and the presence of stressors. A detailed history and examination are required to assess for alarm symptoms and signs. The presence of alarm symptoms increases the chances of organic etiology for RAP. Basic work-ups such as complete blood counts, stool and urine examinations, serum albumin, and inflammatory markers may be required to look for chronic organic etiologies. Fecal calprotectin (FCP) is a highly sensitive tool to differentiate IBD from IBS. Ultrasound abdomen (USG) helps in the evaluation of cholelithiasis, biliary obstruction, chronic pancreatitis, malrotation, and bowel thickening. Endoscopies are useful for peptic ulcer disease, inflammatory bowel diseases, abdominal tuberculosis, Helicobacter pylori infection, etc. Organic causes need specific management. FAPD requires patient counselling and medications. Cognitive behavioral therapy, hypnotherapy, yoga, and percutaneous electrical superficial nerve stimulation are indicated for refractory cases.
复发性腹痛(RAP)定义为在3个月内至少出现3次腹痛发作,其病因包括器质性和功能性两种。高达95%的RAP病因是功能性腹痛障碍(FAPD)。消化性溃疡病、胆石症、慢性胰腺炎、腹部结核、炎症性肠病(IBD)、寄生虫感染和尿路感染(UTI)是RAP突出的器质性病因。发达国家公布的数据显示,儿童FAPD的合并患病率为13.5%,其中肠易激综合征(IBS)是最常见的亚型。评估包括询问疼痛特征、相关症状以及是否存在应激源。需要详细的病史和检查来评估警示症状和体征。警示症状的出现增加了RAP器质性病因的可能性。可能需要进行全血细胞计数、粪便和尿液检查、血清白蛋白及炎症标志物等基础检查,以寻找慢性器质性病因。粪便钙卫蛋白(FCP)是区分IBD和IBS的高灵敏度工具。腹部超声(USG)有助于评估胆石症、胆道梗阻、慢性胰腺炎、肠旋转不良和肠壁增厚。内镜检查对消化性溃疡病、炎症性肠病、腹部结核、幽门螺杆菌感染等有用。器质性病因需要进行针对性治疗。FAPD需要对患者进行咨询并给予药物治疗。认知行为疗法、催眠疗法、瑜伽和经皮电刺激浅表神经疗法适用于难治性病例。