普通狨猴的肾细胞癌：首例报告及非人灵长类文献简要综述
Renal Cell Carcinoma in a Common Marmoset: First Report and a Brief Review of Nonhuman Primate Literature.
作者信息
Battee Taysia, Gonzalez Olga, Medlin Phil S, Dick Edward J, Shivanna Vinay
机构信息
Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, Texas, USA.
Joint Pathology Center, Silver Spring, Maryland, USA.
出版信息
J Med Primatol. 2025 Apr;54(2):e70014. doi: 10.1111/jmp.70014.
Renal cell carcinoma (RCC) is a malignant form of urogenital cancer that arises from renal tubular epithelial cells. Here, we describe a case of renal cell carcinoma in a common marmoset (Callithrix jacchus). Immunohistochemistry demonstrated positive reactivity for PAX8 and CD10 in the renal neoplasm. We review 115 cases of spontaneous renal tumors in nonhuman primates (NHP) reported in the literature and from the Southwest National Primate Research Center records. Across all NHPs, malignant renal neoplasms were more frequent than benign. There appears to be a male sex predilection for renal tumors in baboons. This is the first reported case of renal cell carcinoma in a marmoset.
肾细胞癌（RCC）是一种起源于肾小管上皮细胞的泌尿生殖系统恶性肿瘤。在此，我们描述了一例普通狨猴（Callithrix jacchus）患肾细胞癌的病例。免疫组织化学显示肾肿瘤中PAX8和CD10呈阳性反应。我们回顾了文献报道的以及西南国家灵长类动物研究中心记录的115例非人灵长类动物（NHP）自发性肾肿瘤病例。在所有非人灵长类动物中，恶性肾肿瘤比良性肾肿瘤更常见。狒狒的肾肿瘤似乎存在雄性偏好。这是首次报道的狨猴肾细胞癌病例。
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