Zöller M, Mätz-Rensing K, Fahrion A, Kaup F-J
German Primate Center, Göttingen, Germany.
Vet Pathol. 2008 Jan;45(1):80-4. doi: 10.1354/vp.45-1-80.
Necropsy of a 17-month-old male common marmoset (Callithrix jacchus) with a history of increased abdominal girth resulted in the finding of a unilateral polycystic renal neoplasm. Detailed histopathologic and immunohistochemical investigations revealed different tissue types within the tumor including stromal connective tissue and fusiform mesenchymal cell formations surrounding blastemal cells as well as different developmental stages of organ-specific epithelial cells accompanied by extensive cyst formation. Metastases were not observed. In consideration of the macroscopic, histologic, and immunohistochemical findings, the tumor was classified as a nephroblastoma closely resembling the so-called Wilms' tumor, a malignant embryonic renal tumor frequently observed in humans, especially in young children. In contrast, this tumor entity has rarely been observed in nonhuman primates. This report represents the first documented case of a cystic variant of nephroblastoma in a nonhuman primate.
对一只17个月大、有腹围增大病史的雄性普通狨猴（Callithrix jacchus）进行尸检，发现单侧多囊性肾肿瘤。详细的组织病理学和免疫组织化学研究显示，肿瘤内有不同的组织类型，包括间质结缔组织和围绕胚基细胞的梭形间充质细胞形成，以及器官特异性上皮细胞的不同发育阶段，并伴有广泛的囊肿形成。未观察到转移。考虑到宏观、组织学和免疫组织化学结果，该肿瘤被分类为肾母细胞瘤，与所谓的威尔姆斯瘤非常相似，后者是一种在人类尤其是幼儿中常见的恶性胚胎性肾肿瘤。相比之下，这种肿瘤实体在非人类灵长类动物中很少见。本报告是首次记录的非人类灵长类动物肾母细胞瘤囊性变体病例。
