Sung Jung Yeol, Deng Zixiao, Kim Sung Woo
Department of Animal Science, North Carolina State University, Raleigh, NC 27695, USA.
Antibiotics (Basel). 2025 Mar 14;14(3):301. doi: 10.3390/antibiotics14030301.
Antibiotics at subtherapeutic levels have been used in pig diets as antimicrobial growth promoters. However, concerns about antibiotic resistance have increased the demand for alternatives to these antimicrobial growth promoters. This review paper explores the mechanisms through which antimicrobial growth promoters and their alternatives exert their antimicrobial effects. Additionally, this systemic review also covers how modulation of intestinal microbiota by antimicrobial growth promoters or their alternatives affects intestinal health and, subsequently, growth of pigs. The mechanisms and effects of antimicrobial growth promoters and their alternatives on intestinal microbiota, intestinal health, and growth are diverse and inconsistent. Therefore, pig producers should carefully assess which alternative is the most effective for optimizing both profitability and the health status of pigs in their production system.
亚治疗水平的抗生素已被用于猪的日粮中作为抗菌生长促进剂。然而，对抗生素耐药性的担忧增加了对这些抗菌生长促进剂替代品的需求。这篇综述文章探讨了抗菌生长促进剂及其替代品发挥抗菌作用的机制。此外，这项系统综述还涵盖了抗菌生长促进剂或其替代品对肠道微生物群的调节如何影响肠道健康，进而影响猪的生长。抗菌生长促进剂及其替代品对肠道微生物群、肠道健康和生长的作用机制及影响是多样且不一致的。因此，养猪生产者应仔细评估哪种替代品对优化其生产系统中猪的盈利能力和健康状况最有效。
