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应对抗微生物药物耐药性:一种从水中去除抗生素的可持续方法。

Tackling Antimicrobial Resistance: A Sustainable Method for the Removal of Antibiotics from Water.

作者信息

Abudu Lekan, Bhosale Rutuja C, Arnscheidt Joerg, Tretsiakova-McNally Svetlana, O'Hagan Barry, Adeyemi David K, Oluseyi Temilola, Adams Luqman A, Coleman Heather M

机构信息

School of Pharmacy and Pharmaceutical Sciences, Ulster University, Coleraine BT52 1SA, UK.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Lagos, Lagos 100272, Nigeria.

出版信息

Antibiotics (Basel). 2025 Mar 19;14(3):324. doi: 10.3390/antibiotics14030324.

Abstract

: The presence of antibiotic residues in the aquatic environment is a likely contributor to the current increase in antibiotic resistance, posing a significant threat to global health. This study investigated the use of a low-cost and sustainable material based on sawdust with the purpose of removing rifampicin residues from water. : The sawdust was pretreated with 2M sulfuric acid and was characterized using Fourier Transform Infrared spectroscopy (FT-IR), a Mastersizer, scanning electron microscopy (SEM), an elemental analyser, and the pH point of zero charge (pH). The batch adsorption process was conducted using both raw and treated sawdust to determine the effect of contact time, temperature, pH, adsorbent dosage, and the initial concentration of antibiotic dissolved in water. : The results revealed that the chemical pretreatment of raw sawdust significantly improved its adsorption capacity. The highest removal efficiency of 65% was achieved using an adsorbent dosage of 31.3 g/L. The thermodynamic studies demonstrated that the process was spontaneous and governed by physisorption within the studied temperature range (293.15 K-318.15 K), being more favourable at higher temperatures. The interactions between the functional groups of sawdust and the rifampicin molecules included electrostatic attraction, hydrogen bonding, and π-π interactions. : This research highlights the potential of utilizing waste as a valuable and effective adsorbent of residual antibiotics from water, thus contributing to the sustainable practices of solid waste management and water treatment.

摘要

水生环境中抗生素残留的存在可能是当前抗生素耐药性增加的一个因素,对全球健康构成重大威胁。本研究调查了使用一种基于锯末的低成本且可持续的材料从水中去除利福平残留的情况。锯末用2M硫酸进行预处理,并使用傅里叶变换红外光谱(FT-IR)、激光粒度分析仪、扫描电子显微镜(SEM)、元素分析仪和零电荷点pH值进行表征。使用未经处理和经处理的锯末进行批量吸附过程,以确定接触时间、温度、pH值、吸附剂用量以及水中溶解抗生素的初始浓度的影响。结果表明,对原始锯末进行化学预处理显著提高了其吸附能力。使用31.3 g/L的吸附剂用量时,去除效率最高可达65%。热力学研究表明,该过程是自发的,在所研究的温度范围(293.15 K - 318.15 K)内受物理吸附控制,在较高温度下更有利。锯末官能团与利福平分子之间的相互作用包括静电吸引、氢键和π-π相互作用。本研究突出了将废物用作从水中有效吸附残留抗生素的有价值材料的潜力,从而有助于固体废物管理和水处理的可持续实践。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c30a/11939547/0544306c1be1/antibiotics-14-00324-g001.jpg

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