细菌糖原的生物合成：鼠伤寒沙门氏菌LT-2中糖原生物合成的遗传和别构调节
Biosynthesis of bacterial glycogen: genetic and allosteric regulation of glycogen biosynthesis in Salmonella typhimurium LT-2.
作者信息
Steiner K E, Preiss J
出版信息
J Bacteriol. 1977 Jan;129(1):246-53. doi: 10.1128/jb.129.1.246-253.1977.
Abstract
Structural gene mutants of the glycogen biosynthetic enzymes adenosine diphosphate glucose pyrophosphorylase (glgC) and glycogen synthase (glgA) were isolated and partially characterized. The cotransduction frequencies of these genes with the aspartic semialdehyde dehydrogenase (asd) and glycerol-3-phosphate dehydrogenase (glpD) genes suggested the unambiguous gene order of glpD glgA glgC asd. The results of the three-factor cross glpD- glgA- glgC+ X glpD+ glgA+ glgC- were consistent with the proposed order. A simultaneous and approximately equivalent derepression of the glgC, glgA, and glgB (branching enzyme) gene products was observed in the late logarithmic-early stationary phase of growth on enriched media. These results are consistent with the coordinately regulated synthesis of the three glycogen biosynthetic enzymes in Salmonella typhimurium.
摘要
分离并部分鉴定了糖原生物合成酶二磷酸腺苷葡萄糖焦磷酸化酶（glgC）和糖原合酶（glgA）的结构基因突变体。这些基因与天冬氨酸半醛脱氢酶（asd）和甘油-3-磷酸脱氢酶（glpD）基因的共转导频率表明了明确的基因顺序：glpD glgA glgC asd。三因子杂交glpD- glgA- glgC+×glpD+ glgA+ glgC-的结果与所提出的顺序一致。在富集培养基上生长的对数后期至稳定期早期，观察到glgC、glgA和glgB（分支酶）基因产物同时且大致等量的去阻遏。这些结果与鼠伤寒沙门氏菌中三种糖原生物合成酶的协调调节合成是一致的。
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