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对胎盘源性妊娠并发症的全球及墨西哥背景的见解。

Insights into the Global and Mexican Context of Placental-Derived Pregnancy Complications.

作者信息

Chavira-Suárez Erika

机构信息

Unidad de Vinculación Científica de la Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM) en el Instituto Nacional de Medicina Genómica (INMEGEN), Mexico City 14610, Mexico.

Departamento de Bioquímica de la Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Mexico City 04360, Mexico.

出版信息

Biomedicines. 2025 Mar 1;13(3):595. doi: 10.3390/biomedicines13030595.

Abstract

Placental-derived pregnancy complications encompass a range of disorders that hinder optimal fetal development, significantly impacting maternal and neonatal health outcomes. Key conditions include placental insufficiency, preeclampsia, fetal growth restriction (FGR) or intrauterine growth restriction (IUGR), fetal overgrowth, and gestational diabetes mellitus (GDM), which together contribute to a heightened risk of preterm birth, perinatal mortality, and long-term developmental challenges in affected infants. These complications are particularly notable because they generate approximately 80% of pregnancy disorders and pose significant public health concerns across diverse global contexts. Their management continues to face challenges, including a lack of consensus on diagnostic criteria and varied implementation of care standards. While imaging techniques like magnetic resonance imaging (MRI) and Doppler ultrasound have emerged as critical tools in clinical assessment, disparities in access to such technologies exacerbate existing inequalities in maternal and fetal health outcomes. Maternal and pregnancy care is a broad range of services aimed at promoting the well-being of women throughout the perinatal period. However, access to these services is often limited by economic, geographical, and sociocultural barriers, particularly for marginalized groups and women in low- and middle-income countries (LMICs). The implementation of targeted interventions designed to address specific obstacles faced by disadvantaged populations is a crucial component of bridging the gap in health equity in maternal care. Public health authorities and policymakers strive to develop evidence-based strategies that address the interplay between healthcare access, socioeconomic factors, and effective interventions in order to mitigate the adverse effects of placental-derived pregnancy complications. Continued research and data collection are essential to inform future policies and practices to improve outcomes for mothers and infants.

摘要

胎盘源性妊娠并发症包括一系列妨碍胎儿最佳发育的疾病,对孕产妇和新生儿健康结局产生重大影响。关键病症包括胎盘功能不全、子痫前期、胎儿生长受限(FGR)或宫内生长受限(IUGR)、胎儿过度生长以及妊娠期糖尿病(GDM),这些病症共同导致早产、围产期死亡率升高以及受影响婴儿面临长期发育挑战的风险增加。这些并发症尤为显著,因为它们导致约80%的妊娠疾病,并在全球不同背景下引发重大公共卫生问题。其管理仍面临挑战,包括诊断标准缺乏共识以及护理标准实施各异。虽然磁共振成像(MRI)和多普勒超声等成像技术已成为临床评估的关键工具,但获取此类技术的差异加剧了孕产妇和胎儿健康结局方面现有的不平等。孕产妇和孕期护理是旨在促进妇女在围产期身心健康的一系列广泛服务。然而,获得这些服务往往受到经济、地理和社会文化障碍的限制,特别是对于边缘化群体以及低收入和中等收入国家(LMICs)的妇女而言。实施旨在解决弱势群体面临的特定障碍的针对性干预措施,是弥合孕产妇护理健康公平差距的关键组成部分。公共卫生当局和政策制定者努力制定基于证据的策略,以应对医疗保健获取、社会经济因素和有效干预措施之间的相互作用,从而减轻胎盘源性妊娠并发症的不利影响。持续的研究和数据收集对于为未来政策和实践提供信息以改善母婴结局至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3273/11940293/a591709427fd/biomedicines-13-00595-g001.jpg

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