Xie Yawen, Chen Xiaoying, Xu Maokai, Zheng Xiaochun
Department of Anesthesiology, Fujian Provincial Hospital, Fuzhou 350001, China.
Biomedicines. 2025 Mar 10;13(3):681. doi: 10.3390/biomedicines13030681.
This review summarizes the existing studies of human proteomics technology in the medical field with a focus on the development mechanism of a disease and its potential in discovering biomarkers. Through a systematic review of the relevant literature, we found the significant advantages and application scenarios of proteomics technology in disease diagnosis, drug development, and personalized treatment. However, the review also identifies the challenges facing proteomics technologies, including sample preparation of low-abundance proteins, massive amounts of data analysis, and how research results can be better used in clinical practice. Finally, this work discusses future research directions, including the development of more effective proteomics technologies, strengthening the integration of multi-source omics technologies, and promoting the application of AI in the human proteome.
本综述总结了人类蛋白质组学技术在医学领域的现有研究，重点关注疾病的发生机制及其在发现生物标志物方面的潜力。通过对相关文献的系统综述，我们发现了蛋白质组学技术在疾病诊断、药物开发和个性化治疗方面的显著优势和应用场景。然而，该综述也指出了蛋白质组学技术面临的挑战，包括低丰度蛋白质的样品制备、海量数据分析以及研究结果如何更好地应用于临床实践。最后，这项工作讨论了未来的研究方向，包括开发更有效的蛋白质组学技术、加强多源组学技术的整合以及推动人工智能在人类蛋白质组中的应用。
