Tricotteaux-Zarqaoui Sophian, Lahimer Marwa, Abou Diwan Maria, Corona Aurélie, Candela Pietra, Cabry Rosalie, Bach Véronique, Khorsi-Cauet Hafida, Benkhalifa Moncef
PERITOX-Périnatalité et Risques Toxiques-UMR_I 01 UPJV/INERIS, Centre Universitaire de Recherche en Santé, CURS-UPJV, University of Picardie Jules Verne, CEDEX 1, Amiens, France.
ART and Reproductive Biology Laboratory, University Hospital and School of Medicine, Amiens, France.
Front Public Health. 2024 Dec 12;12:1466967. doi: 10.3389/fpubh.2024.1466967. eCollection 2024.
Over the last decades, human infertility has become a major concern in public health, with severe societal and health consequences. Growing evidence shows that endocrine disruptors chemicals (EDCs) have been considered as risk factors of infertility. Their presence in our everyday life has become ubiquitous because of their universal use in food and beverage containers, personal care products, cosmetics, phytosanitary products. Exposure to these products has an impact on human reproductive health. Recent studies suggest that women are more exposed to EDCs than men due to higher chemical products use. The aim of this review is to understand the possible link between reproductive disorders and EDCs such as phthalates, bisphenol, dioxins, and pesticides. In women, the loss of endocrine balance leads to altered oocyte maturation, competency, anovulation and uterine disorders, endometriosis, premature ovarian insufficiency (POI) or embryonic defect and decreases the fertilization outcomes. In this review, we consider EDCs effects on the women's reproductive system, embryogenesis, with a focus on associated reproductive pathologies.
在过去几十年中，人类不孕症已成为公共卫生领域的一个主要问题，会产生严重的社会和健康后果。越来越多的证据表明，内分泌干扰化学物质（EDCs）被认为是不孕症的风险因素。由于它们在食品和饮料容器、个人护理产品、化妆品、植物检疫产品中的广泛使用，它们在我们日常生活中的存在已变得无处不在。接触这些产品会对人类生殖健康产生影响。最近的研究表明，由于女性使用的化学产品更多，她们比男性更容易接触到EDCs。这篇综述的目的是了解生殖障碍与邻苯二甲酸盐、双酚、二恶英和农药等EDCs之间可能存在的联系。在女性中，内分泌平衡的丧失会导致卵母细胞成熟、能力改变、无排卵和子宫疾病、子宫内膜异位症、卵巢早衰（POI）或胚胎缺陷，并降低受精成功率。在这篇综述中，我们考虑了EDCs对女性生殖系统、胚胎发生的影响，重点关注相关的生殖病理。
