Climer Sharlee
Alzheimer's Disease Neuroimaging Initiative (ADNI), University of Missouri-St. Louis, St. Louis, MO 63121, USA.
Biomolecules. 2025 Feb 26;15(3):337. doi: 10.3390/biom15030337.
In a systematic explorative study of genetic patterns on chromosome 19, we discovered a pattern comprising 23 SNP alleles that is significantly associated with late-onset Alzheimer's disease (AD). This association was validated using two independent datasets. The pattern includes (), which has a long and disputatious relationship with AD. It also spans () and () and is upstream from (). We utilized population data to observe the frequencies of this genetic pattern for 11 different ancestries and noted that it is highly common for Europeans and relatively infrequent for Africans. This research provides a distinct genetic signature for AD risk, as well as insights into the complicated relationship between this disease and .
在一项对19号染色体上基因模式的系统性探索研究中，我们发现了一种由23个单核苷酸多态性（SNP）等位基因组成的模式，该模式与晚发性阿尔茨海默病（AD）显著相关。这种关联在两个独立的数据集中得到了验证。该模式包括（），它与AD有着长期且有争议的关系。它还跨越了（）和（），并且位于（）的上游。我们利用群体数据观察了这种基因模式在11种不同血统中的频率，发现它在欧洲人中非常常见，而在非洲人中相对较少见。这项研究为AD风险提供了独特的基因特征，也为该疾病与（）之间的复杂关系提供了见解。
