Torres M P, Prange C, Lennon G
Biology and Biotechnology Program, Lawrence Livermore National Laboratory, Livermore, California, 94550, USA.
Genomics. 1998 Oct 15;53(2):239-40. doi: 10.1006/geno.1998.5487.
The mapping position of human endopeptidase 24.15 (THOP1) has previously been reported to be within the linkage region for the late-onset Alzheimer disease AD2 locus on chromosome 19q13.3. After localizing THOP1 to the high-resolution cosmid contig map of human chromosome 19, we found that the previous report was incorrect. Results of the hybridization and FISH mapping of positive clones indicated localization of THOP1 to chromosome 19p13.3 and not 19q13. 3. This localization is a correction of wrong chromosomal delegation and excludes THOP1 from the region that shows evidence of linkage to late-onset familial Alzheimer disease.
人类内肽酶24.15（THOP1）的定位先前已报道在19号染色体19q13.3上迟发性阿尔茨海默病AD2位点的连锁区域内。在将THOP1定位到人类19号染色体的高分辨率黏粒重叠群图谱后，我们发现先前的报道是错误的。阳性克隆的杂交和荧光原位杂交定位结果表明，THOP1定位于19号染色体19p13.3，而非19q13.3。这一定位纠正了错误的染色体定位，并将THOP1排除在与迟发性家族性阿尔茨海默病有连锁证据的区域之外。
