Pereira Ana Filipa, Jota Baptista Catarina, Faustino-Rocha Ana, Oliveira Paula A, Coelho Ana Cláudia
Centre for the Research and Technology of Agroenvironmental and Biological Sciences (CITAB), Inov4Agro, University of Trás-os-Montes e Alto Douro (UTAD), Quinta de Prados, 5001-801 Vila Real, Portugal.
Animal and Veterinary Research Centre (CECAV), Associated Laboratory for Animal and Veterinary Sciences (AL4AnimalS), University of Trás-os-Montes e Alto Douro (UTAD), 5001-801 Vila Real, Portugal.
Animals (Basel). 2025 Mar 13;15(6):818. doi: 10.3390/ani15060818.
Recent advancements in molecular biology have led to the discovery of potential biomarkers for the diagnosis of acute kidney disease (AKD) and chronic kidney disease (CKD). The use of multiple biomarkers in the diagnosis of kidney disease has the potential to enhance both specificity and sensitivity, enabling early detection and intervention that could ultimately reduce morbidity and mortality rates. This review provides an overview of studies on urine and blood biomarkers and examines their utility and significance in various clinical settings. Further and continuous research is needed to support the application of these biomarkers in clinical practice to facilitate early diagnosis, guidance for different interventions, and the monitoring of disease progression.
分子生物学的最新进展已促成急性肾损伤(AKD)和慢性肾脏病(CKD)诊断潜在生物标志物的发现。在肾脏病诊断中使用多种生物标志物有可能提高特异性和敏感性,实现早期检测与干预,最终降低发病率和死亡率。本综述概述了关于尿液和血液生物标志物的研究,并探讨了它们在各种临床环境中的效用和意义。需要进一步持续的研究来支持这些生物标志物在临床实践中的应用,以促进早期诊断、指导不同干预措施以及监测疾病进展。