Oswal Deshna, Angolkar Mubashir, Mahantashetti N S, Dhagavkar Pooja, Haritay Shivani, Godbole Madan
Department of Public Health, Jawaharlal Nehru Medical College, KLE Academy of Higher Education & Research (KAHER), Belagavi, Karnataka, India.
Department of Pediatrics, Jawaharlal Nehru Medical College, KLE Academy of Higher Education & Research (KAHER), Belagavi, Karnataka, India.
J Pediatr Gastroenterol Nutr. 2025 Jun;80(6):1018-1027. doi: 10.1002/jpn3.70033. Epub 2025 Mar 27.
This study aimed to assess the impact of bovine colostrum (BC) on the gut health of the pediatric population.
The systematic review was conducted in accordance with Preferred Reporting Items for Systematic Review and Meta-analysis guidelines 2020. Full-text articles such as randomized control trials, cohort prospective studies, and pilot studies were identified from the following databases: PubMed, Web of Science, ProQuest, Clinicaltrial.gov, and Cochrane. After assessing for inclusion and exclusion criteria, eight studies were finally included and assessed for quality using the Effective Public Health Practice Project scale.
Some studies reported a positive impact of BC on the duration and frequency of diarrheal infection in children, but the overall clinical benefits of BC in the gut health of children remain inconclusive. The studies were heterogeneous with regard to methodology, dose, form of BC used, and outcomes studied; hence, a meta-analysis could not be performed in terms of outcomes assessed.
No conclusion can be drawn regarding the clinical benefits of BC in the gut health of children. Further studies are needed in the pediatric population using BC as an intervention for a variety of gastro-intestinal problems.
本研究旨在评估牛初乳（BC）对儿童肠道健康的影响。
本系统评价按照《系统评价与Meta分析优先报告条目》（PRISMA）2020指南进行。从以下数据库中检索随机对照试验、队列前瞻性研究和试点研究等全文文章：PubMed、科学网、ProQuest、Clinicaltrial.gov和Cochrane。在评估纳入和排除标准后，最终纳入8项研究，并使用有效公共卫生实践项目量表对质量进行评估。
一些研究报告了BC对儿童腹泻感染持续时间和频率的积极影响，但BC对儿童肠道健康的总体临床益处仍不明确。这些研究在方法、剂量、所使用的BC形式和研究结果方面存在异质性；因此，无法根据评估的结果进行Meta分析。
关于BC对儿童肠道健康的临床益处尚无定论。需要在儿科人群中进行进一步研究，将BC用作针对各种胃肠道问题的干预措施。
