Department of Pediatrics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730, China.
Department of Science and Technology, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, China.
Sci Rep. 2019 Feb 28;9(1):3093. doi: 10.1038/s41598-019-39644-x.
This meta-analysis aimed to investigate the protective effects of bovine colostrum against childhood infectious diarrhea. A systematic search was conducted using PubMed, Cochrane Library databases and clinicaltrial.gov. Among 166 research articles, only five RCTs were included into final analysis. Review manager (version 5.2) was used to pool the effect-size across studies. Sensitivity and risk of bias were estimated accordingly. Under a pooled analysis, bovine colostrum consumption correlated with a significant reduction in stool frequency of infectious diarrhea, by 1.42 times per day (95% CI: -2.70, -0.14). Bovine colostrum intervention also reduced occurrence of diarrhea by 71% (pooled OR = 0.29, 95%CI 0.16, 0.52). The OR of positive detection of pathogen in the stool was 0.29 (95%CI 0.08, 0.71) in bovine colostrum treated group, compared with placebo group. In the sensitivity analysis of studies with low risk of biases, bovine colostrum significantly reduced stool frequency, occurrence of diarrhea and pathogen detection. BC and related products have a significant benefit in reducing the frequency and relieving the symptoms of childhood infectious diarrhea.
本荟萃分析旨在探讨牛初乳对儿童感染性腹泻的保护作用。通过PubMed、Cochrane 图书馆数据库和 clinicaltrial.gov 进行了系统检索。在 166 篇研究文章中，只有 5 项 RCT 被纳入最终分析。使用 Review Manager（版本 5.2）对研究间的效应大小进行合并分析。相应地估计了敏感性和偏倚风险。在荟萃分析中，牛初乳的摄入与感染性腹泻的粪便频率显著降低相关，每天减少 1.42 倍（95%CI：-2.70，-0.14）。牛初乳干预也使腹泻的发生率降低了 71%（合并 OR = 0.29，95%CI 0.16，0.52）。与安慰剂组相比，牛初乳治疗组粪便中病原体检测阳性的 OR 为 0.29（95%CI 0.08，0.71）。在低偏倚风险研究的敏感性分析中，牛初乳显著降低了粪便频率、腹泻发生率和病原体检测。BC 和相关产品在减少儿童感染性腹泻的频率和缓解症状方面具有显著益处。
