Erkuş Edip, Kotan Rojda, Nasır Binici Doğan
Nephrology Unit, University of Health Sciences Erzurum City Hospital, Erzurum, Turkey.
Internal Medicine Unit, University of Health Sciences Erzurum City Hospital, Erzurum, Turkey.
Int J Artif Organs. 2025 Apr;48(4):229-234. doi: 10.1177/03913988251323758. Epub 2025 Mar 27.
In this study, we aimed to evaluate cognitive functions in Stage 4 and 5 CKD patients using the Montreal Cognitive Assessment (MoCA) Scale, which objectively assesses cognitive dysfunction and various cognitive functions, and to compare them with a control group with normal kidney functions.
All participants in our case-control study were administered the Montreal Cognitive Assessment (MoCA) Test, and total scores, subscale scores, and the presence of cognitive dysfunction were recorded.
When the groups were compared in terms of cognitive dysfunction (CD), 12.9% of the control group and 37.1% of the case group were found to have CD, which was statistically significant. When the groups were compared in terms of data and scale scores, the visual construction subscale score, naming, delayed recall subscale score, and total MoCA score were found to be significantly lower in the case group compared to the control group.
Our study is the first to use the MoCA test with the correct reference range. The significant impairment observed in the cognitive functions of patients with advanced-stage CKD in our study suggests that the decision for renal replacement therapy should not be made by the patient alone, as it may be incorrect.
在本研究中，我们旨在使用蒙特利尔认知评估（MoCA）量表评估4期和5期慢性肾脏病（CKD）患者的认知功能，该量表可客观评估认知功能障碍及各种认知功能，并将其与肾功能正常的对照组进行比较。
我们的病例对照研究中的所有参与者均接受了蒙特利尔认知评估（MoCA）测试，并记录了总分、子量表分数以及认知功能障碍的情况。
在比较两组的认知功能障碍（CD）时，发现对照组中有12.9%的人存在CD，病例组中有37.1%的人存在CD，差异具有统计学意义。在比较两组的数据和量表分数时，发现病例组的视觉构建子量表分数、命名、延迟回忆子量表分数和MoCA总分均显著低于对照组。
我们的研究首次使用了具有正确参考范围的MoCA测试。我们的研究中观察到晚期CKD患者的认知功能有显著损害，这表明不应仅由患者本人决定是否进行肾脏替代治疗，因为这可能是不正确的。
