T-2毒素及其代谢产物对人淋巴细胞有丝分裂原诱导的母细胞化的抑制作用。
Inhibition of mitogen-induced blastogenesis in human lymphocytes by T-2 toxin and its metabolites.
作者信息
Forsell J H, Kateley J R, Yoshizawa T, Pestka J J
出版信息
Appl Environ Microbiol. 1985 Jun;49(6):1523-6. doi: 10.1128/aem.49.6.1523-1526.1985.
Abstract
Concentrations of T-2, HT-2, 3'-OH T-2, 3'-OH HT-2, T-2 triol, and T-2 tetraol toxins which inhibited [3H]thymidine uptake in mitogen-stimulated human peripheral lymphocytes by 50% were 1.5, 3.5, 4.0, 50, 150, and 150 ng/ml, respectively. The results suggested that the initial hydrolysis of T-2 toxin and the hydroxylation of T-2 toxin to 3'-OH T-2 toxin did not significantly decrease the immunotoxicity of the parent molecule, whereas further hydrolysis to T-2 triol and T-2 tetraol toxins or hydroxylation to 3'-OH HT-2 toxin decreased in vitro toxicity for human lymphocytes.
摘要
T-2、HT-2、3'-羟基T-2、3'-羟基HT-2、T-2三醇和T-2四醇毒素抑制丝裂原刺激的人外周血淋巴细胞摄取[3H]胸苷50%时的浓度分别为1.5、3.5、4.0、50、150和150 ng/ml。结果表明，T-2毒素的初始水解以及T-2毒素羟基化为3'-羟基T-2毒素并没有显著降低母体分子的免疫毒性，而进一步水解为T-2三醇和T-2四醇毒素或羟基化为3'-羟基HT-2毒素则降低了对人淋巴细胞的体外毒性。
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本文引用的文献
1
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Appl Environ Microbiol. 1980 Nov;40(5):901-6. doi: 10.1128/aem.40.5.901-906.1980.
2
T-2 metabolites in the excreta of broiler chickens administered 3H-labeled T-2 toxin.给予3H标记的T-2毒素的肉鸡排泄物中的T-2代谢物。
Appl Environ Microbiol. 1980 Jun;39(6):1172-7. doi: 10.1128/aem.39.6.1172-1177.1980.
3
Experimental cryptococcosis in mice treated with diacetoxyscirpenol, a mycotoxin of fusarium.用镰刀菌的霉菌毒素二乙酰氧基雪腐镰刀菌烯醇处理的小鼠实验性隐球菌病
Sabouraudia. 1981 Dec;19(4):311-3. doi: 10.1080/00362178185380501.
4
Induction of DNA single-strand breaks by T2 toxin, a trichothecene metabolite of fusarium: effect on lymphoid organs and liver.镰刀菌的单端孢霉烯族毒素代谢产物T2毒素诱导DNA单链断裂：对淋巴器官和肝脏的影响
Mutat Res. 1981 Feb;88(2):115-23. doi: 10.1016/0165-1218(81)90010-0.
5
Metabolic fate of T-2 toxin in a lactating cow.T-2毒素在泌乳奶牛体内的代谢命运
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6
[Effects of diacetoxyscirpenol on experimental candidiasis of mice].
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7
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8
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9
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Jpn J Med Sci Biol. 1984 Apr;37(2):97-104. doi: 10.7883/yoken1952.37.97.
10
Effect of subclinical levels of T-2 toxin on the bovine cellular immune system.亚临床水平的T-2毒素对牛细胞免疫系统的影响。
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