Ma Xu, Su Hong, Liu Yongming, Chen Fenghua, Xue Rongrong
College of Chemistry and Materials Science, Fujian Normal University Fuzhou 350117 Fujian China.
School of Resources and Chemical Engineering, Sanming University Sanming 365004 Fujian China
RSC Adv. 2025 Mar 27;15(12):9348-9358. doi: 10.1039/d4ra08796h. eCollection 2025 Mar 21.
Quercetin (QUE) is a functional flavonoid molecule with low water solubility. The study of its amorphous solid dispersions (ASDs) is still insufficient. This work reveals that the solubility of the physical mixtures of anhydrous QUE and polymers (PVP or soluplus) is better than that of the ASDs of QUE and the corresponding polymers. Gel-like phase separation occurring during the QUE ASDs dissolution process (weak in ASDs with PVP and strong in ASDs with soluplus) reduces the driving force for QUE release, which makes research on the QUE ASDs insufficient, and can be avoided in the QUE physical mixtures with polymers. Combination of metastable polymorph and polymer is a feasible strategy for improving the solubility of poorly water-soluble molecules whose ASDs encounter the gel-like phase separation.
槲皮素（QUE）是一种水溶性低的功能性黄酮类分子。对其无定形固体分散体（ASD）的研究仍不充分。这项工作表明，无水QUE与聚合物（PVP或尤特奇）物理混合物的溶解度优于QUE与相应聚合物的ASD。QUE的ASD溶解过程中发生的凝胶状相分离（在与PVP的ASD中较弱，在与尤特奇的ASD中较强）降低了QUE释放的驱动力，这使得对QUE的ASD研究不足，而在QUE与聚合物的物理混合物中可以避免这种情况。亚稳多晶型物与聚合物的组合是提高ASD遇到凝胶状相分离的难溶性分子溶解度的可行策略。
