Distler W, Hüsgen P, Kozlowski P, Terinde R
Arch Gynecol. 1985;236(3):153-60. doi: 10.1007/BF02133958.
Concentrations of estradiol (E2), progesterone (P), and 170H-progesterone (170H-P) were measured by radioimmunoassay in serum samples obtained from a group of 98 women with threatened (n = 60), incomplete (n = 22) or missed (n = 16) abortion between the 4th and 17th week of pregnancy. The diagnosis was based on the clinical symptoms and the results of ultrasound scanning. In threatened abortion 54, out of 60 E2 values were within the 95% normal range, including most of the cases in which abortion occurred later. In incomplete abortion 18 of 21 E2 values were below the lower 95% confidence limit. In missed abortion, 11 of 15 E2 values were abnormal, being below the 95% normal range. Similar patterns in women with threatened, incomplete or missed abortion can be observed for values of P and 170H-P. Our results indicate that serum determinations of ovarian and placental steroids in women with early pregnancy failure are not of great clinical value.
采用放射免疫分析法测定了98例妊娠4至17周出现先兆流产（n = 60）、不全流产（n = 22）或稽留流产（n = 16）的妇女血清样本中的雌二醇（E2）、孕酮（P）和17α-羟孕酮（17α-OH-P）浓度。诊断基于临床症状和超声扫描结果。在先兆流产中，60例中有54例E2值在95%正常范围内，包括大多数流产发生较晚的病例。在不全流产中，21例中有18例E2值低于95%置信下限。在稽留流产中，15例中有11例E2值异常，低于95%正常范围。对于P和17α-OH-P的值，先兆流产、不全流产或稽留流产的妇女中可观察到类似模式。我们的结果表明，早期妊娠失败妇女血清中卵巢和胎盘类固醇的测定没有很大的临床价值。
