Ballantyne G H, Reigel M M, Wolff B G, Ilstrup D M
Ann Surg. 1985 Aug;202(2):209-14. doi: 10.1097/00000658-198508000-00011.
Data on survival and survival free-from-recurrence were analyzed retrospectively in a group of 571 women who had undergone curative resection for colon cancer at the Mayo Clinic between 1972 and 1978. Of these women, 75 (group 1) had required bilateral oophorectomy before or at colon resection, while 496 (group 2) retained one or both ovaries. Average age, location and grade of tumor, and duration of follow-up were similar for both groups. Five-year-survival rate for the 571 women was 73.6%, as compared with 84.3% for matched controls. The 5-year survival rates were not significantly different for group 1 (78.0%) and group 2 (72.9%). Five-year survival free-from-recurrence also was not significantly different (82.9%, group 1 and 79.5%, group 2). Women in group 1 who had grade 1 or 2 tumors or lesions in the sigmoid and cecum fared the best (no significant difference from controls). Incidence studies of ovarian metastases from colon cancers suggest that three to eight per cent of women should benefit from bilateral oophorectomy. This agrees with the difference in survival observed between groups 1 and 2 in this study. Our sample size is too small to statistically confirm the reliability of this difference. The design of a prospective study testing this hypothesis is outlined.
对1972年至1978年间在梅奥诊所接受结肠癌根治性切除术的571名女性患者的生存及无复发生存数据进行了回顾性分析。在这些女性中，75名（第1组）在结肠切除术前或术中需要进行双侧卵巢切除术，而496名（第2组）保留了一个或两个卵巢。两组患者的平均年龄、肿瘤位置和分级以及随访时间相似。571名女性的五年生存率为73.6%，而匹配对照组为84.3%。第1组（78.0%）和第2组（72.9%）的五年生存率无显著差异。五年无复发生存率也无显著差异（第1组为82.9%，第2组为79.5%）。第1组中肿瘤分级为1级或2级以及病变位于乙状结肠和盲肠的女性预后最佳（与对照组无显著差异）。结肠癌卵巢转移的发病率研究表明，3%至8%的女性应能从双侧卵巢切除术中获益。这与本研究中第1组和第2组观察到的生存差异相符。我们的样本量太小，无法从统计学上证实这种差异的可靠性。本文概述了一项检验该假设的前瞻性研究设计。
