Gustafsson Anna, Hjalte Frida, Norlin Jenny, Odin Per, Hagell Peter
The Swedish Institute for Health Economics, Lund, Sweden.
Department of Neurology, Rehabilitation Medicine, Memory Disorders, and Geriatrics, Skåne University Hospital, Malmö, Sweden.
J Neurol. 2025 Mar 28;272(4):297. doi: 10.1007/s00415-025-13044-w.
Parkinson's disease (PD) is a neurodegenerative disorder associated with substantial costs that escalate as the disease progresses. Previous research has explored the relationship between disease progression, motor symptoms, and the economic burden of PD. However, there is a lack of studies focusing on the relationship between costs and non-motor symptoms (NMS).
To examine the association between societal costs and NMS in individuals with PD in Sweden.
Persons with idiopathic PD in the Swedish Parkinson's disease registry from the region of Skåne with registrations of non-motor symptoms questionnaire (NMSQ) were included. Identified subjects were linked to administrative health care data registries, to estimate annual costs. A generalized linear model was used to assess the relationship between NMS and costs.
NMS were present in 74% (n = 703) of the study population, with a mean of 6.9 symptoms per observation. The number of NMS increased with disease duration, and costs were higher for those with a greater number of symptoms. Formal care costs were 3.8 times higher in observations with at least 10 NMS. Experiencing hallucinations and/or delusions was associated with an 80-94% increase in total costs, corresponding to an additional SEK 107,000-121,000 per patient year.
Presence of NMS in PD is associated with substantial societal costs. Findings from this study highlight the necessity for comprehensive management strategies that address both motor and non-motor symptoms to potentially alleviate the burden on patients and the healthcare system.
帕金森病（PD）是一种神经退行性疾病，随着疾病进展，相关成本会大幅增加。以往研究探讨了疾病进展、运动症状与帕金森病经济负担之间的关系。然而，缺乏关注成本与非运动症状（NMS）之间关系的研究。
研究瑞典帕金森病患者的社会成本与非运动症状之间的关联。
纳入瑞典斯科讷地区帕金森病登记处登记了非运动症状问卷（NMSQ）的特发性帕金森病患者。将确定的研究对象与行政医疗保健数据登记处相链接，以估算年度成本。采用广义线性模型评估非运动症状与成本之间的关系。
74%（n = 703）的研究人群存在非运动症状，每次观察的症状平均数为6.9个。非运动症状的数量随疾病持续时间增加，症状数量较多者的成本更高。至少有10种非运动症状的观察对象的正规护理成本高出3.8倍。出现幻觉和/或妄想与总成本增加80% - 94%相关，相当于每位患者每年额外增加107,000 - 121,000瑞典克朗。
帕金森病患者存在非运动症状与巨大的社会成本相关。本研究结果凸显了采取综合管理策略的必要性，该策略应同时解决运动和非运动症状，以潜在减轻患者和医疗系统的负担。
