Dönmez Mehmet Fatih, Balci Nur, Sunkar Aslı Ergene, Toygar Hilal, Kantarcı Alpdoğan
Vocational School of Health Services, Department of Dental Services, Toros University, Mersin, Turkey.
Institute of Health Sciences, Department of Periodontology, Istanbul Medipol University, Istanbul, Turkey.
J Periodontol. 2025 Mar 28. doi: 10.1002/JPER.24-0574.
Periodontitis is a chronic inflammatory condition that affects the supporting structures of the teeth. It is closely associated with oxidative stress and inflammation. Taurine, a semi-essential amino acid recognized for its antioxidant and anti-inflammatory properties, has not been extensively investigated in the context of periodontitis. This pilot study sought to evaluate the levels of taurine and inflammatory cytokines, including interleukin-1 beta (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α), in the gingival crevicular fluid (GCF) of individuals with periodontitis.
Systemically healthy participants with periodontitis and periodontally healthy individuals were enrolled. GCF samples were collected, and clinical periodontal parameters such as bleeding on probing (BOP), clinical attachment loss (CAL), plaque index (PI), and probing depth (PD) were documented. The levels of taurine, TNF-α, IL-1ß, and IL-16 in the GCF were quantified using enzyme-linked immunosorbent assay (ELISA).
This case-control pilot study included 40 individuals, divided into 2 groups: 20 periodontally healthy individuals and 20 with stage III, grade B generalized periodontitis. The periodontitis group exhibited significantly higher clinical periodontal parameters than the healthy group (p < 0.05). Taurine levels in GCF were significantly lower, while TNF-α levels were higher in the periodontitis group (p < 0.05). No significant differences between groups were found in IL-6 and IL-1β levels (p > 0.05). A moderate positive correlation was observed between BOP and TNF-α levels (r = 0.581, p = 0.007).
These findings indicated increased taurine levels were associated with periodontal health.
Periodontitis is a serious disease of the gums that can lead to the loss of teeth by destruction of the supporting tissues. This study investigated the potential link between taurine, a naturally occurring compound with anti-inflammatory properties, and periodontitis. We measured levels of taurine and inflammation-related proteins in gum fluid from individuals with healthy gums and those with periodontitis. Subjects with periodontitis had lower levels of taurine and higher levels of the inflammatory protein TNF-α compared to individuals with healthy gums, suggesting that taurine could be involved in the inflammation processes of periodontitis.
牙周炎是一种影响牙齿支持结构的慢性炎症性疾病。它与氧化应激和炎症密切相关。牛磺酸是一种因其抗氧化和抗炎特性而被认可的半必需氨基酸，在牙周炎背景下尚未得到广泛研究。这项初步研究旨在评估牙周炎患者龈沟液（GCF）中牛磺酸和炎症细胞因子的水平，包括白细胞介素-1β（IL-1β）、白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）。
纳入全身健康的牙周炎患者和牙周健康个体。收集GCF样本，并记录临床牙周参数，如探诊出血（BOP）、临床附着丧失（CAL）、菌斑指数（PI）和探诊深度（PD）。使用酶联免疫吸附测定（ELISA）对GCF中牛磺酸、TNF-α、IL-1β和IL-16的水平进行定量。
这项病例对照初步研究包括40名个体，分为2组：20名牙周健康个体和20名患有III期B级广泛性牙周炎的患者。牙周炎组的临床牙周参数显著高于健康组（p < 0.05）。牙周炎组GCF中的牛磺酸水平显著较低，而TNF-α水平较高（p < 0.05）。两组之间的IL-6和IL-1β水平无显著差异（p > 0.05）。观察到BOP与TNF-α水平之间存在中度正相关（r = 0.581，p = 0.007）。
这些发现表明牛磺酸水平升高与牙周健康有关。
牙周炎是一种严重的牙龈疾病，可通过破坏支持组织导致牙齿脱落。本研究调查了具有抗炎特性的天然化合物牛磺酸与牙周炎之间的潜在联系。我们测量了健康牙龈个体和牙周炎患者牙龈液中牛磺酸和炎症相关蛋白的水平。与健康牙龈个体相比，牙周炎患者的牛磺酸水平较低，炎症蛋白TNF-α水平较高，这表明牛磺酸可能参与了牙周炎的炎症过程。
