胃癌中生长分化因子作为治疗靶点和预后生物标志物的综合分析。
Comprehensive analysis of GDFs as therapeutic targets and prognosis biomarkers in gastric cancer.
作者信息
Zhu Minjie, Hong Jiawei, Liu Xianfang, Wang Haiming, Lou Longquan
机构信息
Department of General Surgery, Hangzhou Third People's Hospital, Hangzhou, Zhejiang, China.
Department of Hepatobiliary and Pancreatic Surgery, Key Laboratory of Artificial Organs and Computational Medicine of Zhejiang Province, Shulan (Hangzhou) Hospital, Shulan International Medical College, Zhejiang Shuren University, Hangzhou, P.R. China.
出版信息
Medicine (Baltimore). 2025 Mar 28;104(13):e41976. doi: 10.1097/MD.0000000000041976.
Growth/differentiation factors (GDFs, GDF1-3, GDF5-7, GDF9-11, and GDF15) belong to a subfamily of the transforming growth factor-β. GDFs play an important role in morphogenetic and developmental activities in many tissues. And many GDFs family numbers have been observed to be correlated with various types of tumors. However, the diverse expression patterns and prognostic values of ten GDFs in gastric cancer (GC) have yet to be analyzed. Herein we investigated the transcriptional and survival data of GDFs in patients with GC from the Gene Expression Profiling Interactive Analysis, The Cancer Genome Atlas, cBioPortal, Tumor Immune Estimation Resource, Tumor Immune Syngeneic Mouse, UALCAN, Human Protein Atlas Gene Expression Omnibus and The Database for Annotation, Visualization and Integrated Discovery databases. We found that multiple GDF family members are highly expressed in GC, which can prompt diagnosis and evaluate prognosis, and can be used as target points for GC immunotherapy.
生长/分化因子（GDFs，GDF1 - 3、GDF5 - 7、GDF9 - 11和GDF15）属于转化生长因子-β亚家族。GDFs在许多组织的形态发生和发育活动中发挥重要作用。并且已观察到许多GDF家族成员与各种类型的肿瘤相关。然而，十种GDFs在胃癌（GC）中的不同表达模式和预后价值尚未得到分析。在此，我们从基因表达谱交互分析、癌症基因组图谱、cBioPortal、肿瘤免疫评估资源、肿瘤免疫同基因小鼠、UALCAN、人类蛋白质图谱基因表达综合数据库以及注释、可视化和综合发现数据库中调查了GC患者中GDFs的转录和生存数据。我们发现多个GDF家族成员在GC中高表达，这可以促进诊断和评估预后，并可作为GC免疫治疗的靶点。
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