Candelise L, Landi G, Orazio E N, Boccardi E
Arch Neurol. 1985 Jul;42(7):661-3. doi: 10.1001/archneur.1985.04060070051014.
Prognostic significance of hyperglycemia on short-term survival was evaluated in 72 patients with acute hemispheric stroke. All patients were admitted within 48 hours of onset, and the neurologic deficit was assessed by means of a standardized score. A computed tomogram was taken in all cases on admission. Mortality was higher in hyperglycemic patients with no history of diabetes mellitus (78%) than in diabetic (45%) and in normoglycemic nondiabetic (29%) patients. In nondiabetic patients, the glucose level correlated with the neurologic score and with lesion size on computed tomogram. Reactive hyperglycemia due to a major stress response accounts for the worse prognosis of these patients. This correlation was not found in diabetic patients. Preexisting hyperglycemia, as well as systemic complications, could explain the higher mortality in these patients compared with normoglycemic nondiabetic patients.
对72例急性半球性卒中患者评估了高血糖对短期生存的预后意义。所有患者均在发病后48小时内入院，并通过标准化评分评估神经功能缺损。所有病例入院时均进行了计算机断层扫描。无糖尿病病史的高血糖患者死亡率（78%）高于糖尿病患者（45%）和血糖正常的非糖尿病患者（29%）。在非糖尿病患者中，血糖水平与神经功能评分以及计算机断层扫描显示的病变大小相关。由重大应激反应引起的反应性高血糖是这些患者预后较差的原因。在糖尿病患者中未发现这种相关性。与血糖正常的非糖尿病患者相比，既往存在的高血糖以及全身并发症可以解释这些患者较高的死亡率。
