Mano Geran Suria, Krishnasamy Naido Sargunann Naidu, Hline Aye Thida
Cardiology Department, Queen's Hospital, Barking, Havering, and Redbridge University Hospitals NHS Trust, Romford, United Kingdom.
Diabetes and Endocrinology Department, Whittington Hospital NHS Foundation Trust, London, United Kingdom.
JACC Case Rep. 2025 Mar 19;30(6 Pt 2):102989. doi: 10.1016/j.jaccas.2024.102989. Epub 2025 Jan 22.
Carcinoid heart disease (CHD), despite its rarity, is a serious complication of carcinoid syndrome (CS). Approximately 50% of patients with CS will develop CHD during the course of their disease. It predominantly affects the right-sided heart valves, leading to valve defect and right heart failure. In patients with advanced functional neuroendocrine tumors, diagnosing and managing CHD remains a challenge.
A 71-year-old male with a metastatic midgut neuroendocrine tumor and CS presented with worsening right heart failure. Despite initiating treatment appropriately, he deteriorated and ultimately died, highlighting the difficulty of CHD management in advanced cases.
Early detection and prompt management of CS are vital to prevent the progression to CHD. Therefore, a carefully planned sequential management approach should be developed for a generalized adaptation. Multidisciplinary care is vital, and new percutaneous interventions could provide promising options for high-risk patients.
TAKE-HOME MESSAGE: Routine screening of CHD in NET patients, timely intervention, and specialized multidisciplinary management are vital for improving outcomes in CHD.
类癌性心脏病（CHD）虽罕见，但却是类癌综合征（CS）的严重并发症。约50%的CS患者在病程中会发展为CHD。它主要影响右侧心脏瓣膜，导致瓣膜缺陷和右心衰竭。在晚期功能性神经内分泌肿瘤患者中，CHD的诊断和管理仍然是一项挑战。
一名71岁男性，患有转移性中肠神经内分泌肿瘤和CS，出现右心衰竭加重。尽管进行了适当的治疗，但他病情恶化最终死亡，凸显了晚期CHD管理的困难。
CS的早期检测和及时管理对于预防进展为CHD至关重要。因此，应制定精心规划的序贯管理方法以实现普遍适用。多学科护理至关重要，新的经皮干预措施可为高危患者提供有前景的选择。
对神经内分泌肿瘤患者进行CHD常规筛查、及时干预和专门的多学科管理对于改善CHD的治疗效果至关重要。
