较高的身体圆润度指数（BRI）会增加18至45岁美国女性的不孕几率。

Higher body roundness index (BRI) increases infertility among U.S. women aged 18-45 years.

作者信息

Gong Hongyang, Duan Shuqin, Choi Seok, Huang Shaoqun

机构信息

Department of Oncology Surgery, Fuzhou Hospital of Traditional Chinese Medicine Affiliated to Fujian University of Traditional Chinese Medicine, No.102 Gudong Road, Gulou District, Fuzhou City, Fujian Province, 350001, China.

Department of Physiology, College of Medicine, Chosun University, Gwangju, Korea.

出版信息

BMC Endocr Disord. 2024 Dec 18;24(1):266. doi: 10.1186/s12902-024-01799-8.

DOI:10.1186/s12902-024-01799-8

PMID:39696159

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11654071/

Abstract

OBJECTIVE

Infertility is associated with obesity. The Body Roundness Index (BRI) is a body measurement index related to obesity that more accurately assesses body and visceral fat levels. However, the relationship between BRI and infertility remains unclear. Therefore, this study aims to determine the relationship between BRI and infertility.

METHODS

This study utilized data from the National Health and Nutrition Examination Survey (NHANES) from 2013 to 2018 and included 3,528 women aged 18-45 years. Multivariate logistic regression was employed to investigate the association between BRI and infertility. Restricted cubic spline (RCS) analysis explored the linear or non-linear relationship between BRI and infertility. Interaction analyses were conducted on subgroups to validate the findings. To verify the robustness of the results, we performed several sensitivity analyses, including propensity score matching(PSM) and multiple imputations for missing data. Furthermore, the predictive capabilities of various anthropometric indices-including BRI, weight-adjusted waist index (WWI), body mass index (BMI), and weight-on infertility incidence were assessed using Receiver Operating Characteristic (ROC) curve analysis.

RESULTS

There was a significant positive association between BRI and infertility. After adjusting for covariates, for each unit increase in BRI, there was a 12% increase in the probability of infertility (P < 0.001). This positive correlation persisted when BRI was categorized into quartiles. Moreover, as BRI increased, there was a trend towards higher infertility prevalence (P for trend < 0.001). The dose-response curve indicated a linear association between BRI and infertility, with higher BRI associated with higher infertility risk. The correlation between BRI and infertility persisted in subgroup analysis and multiple imputations. The ROC curve analysis revealed that BRI had a superior predictive capability compared to traditional obesity indices, with an area under the curve (AUC) of 0.618 (95% CI, 0.588-0.648).

CONCLUSION

The results of this study show a strong positive correlation between BRI and the prevalence of infertility.

CLINICAL TRIAL NUMBER

Not Applicable.

摘要

目的

不孕症与肥胖有关。身体圆润度指数（BRI）是一种与肥胖相关的身体测量指数，能更准确地评估身体和内脏脂肪水平。然而，BRI与不孕症之间的关系仍不明确。因此，本研究旨在确定BRI与不孕症之间的关系。

方法

本研究使用了2013年至2018年美国国家健康与营养检查调查（NHANES）的数据，纳入了3528名年龄在18至45岁之间的女性。采用多变量逻辑回归来研究BRI与不孕症之间的关联。受限立方样条（RCS）分析探讨了BRI与不孕症之间的线性或非线性关系。对亚组进行交互分析以验证研究结果。为验证结果的稳健性，我们进行了多项敏感性分析，包括倾向得分匹配（PSM）和对缺失数据的多重插补。此外，使用受试者工作特征（ROC）曲线分析评估了各种人体测量指数（包括BRI、体重调整腰围指数（WWI）、体重指数（BMI））对不孕症发生率的预测能力。

结果

BRI与不孕症之间存在显著的正相关。在调整协变量后，BRI每增加一个单位，不孕症的发生概率增加12%（P < 0.001）。当将BRI分为四分位数时，这种正相关仍然存在。此外，随着BRI的增加，不孕症患病率有上升趋势（趋势P < 0.001）。剂量反应曲线表明BRI与不孕症之间存在线性关联，BRI越高，不孕症风险越高。在亚组分析和多重插补中，BRI与不孕症之间的相关性仍然存在。ROC曲线分析显示，与传统肥胖指数相比，BRI具有更好的预测能力，曲线下面积（AUC）为0.618（95%CI，0.588 - 0.648）。