Yu Qiong, Ma Jinbao, Ma Zhiming, Shi Guang
Department of Hematology and Oncology, the Second Hospital of Jilin University, No. 218, Zi qiang Street, Changchun, 130041, Jilin, P.R. China.
Department of Drug-resistance Tuberculosis, Xi'an Chest Hospital, Xi'an, 710000, P.R. China.
Sci Rep. 2025 Mar 28;15(1):10763. doi: 10.1038/s41598-025-95241-1.
Klotho, a protein primarily expressed in the kidneys and brain, plays a critical role in aging, vascular health, and various metabolic processes. Lower serum Klotho levels have been associated with several chronic diseases, including cardiovascular disease, diabetes, and kidney disease. Although the role of Klotho in platelet regulation remains underexplored, thrombocytosis may be influenced by Klotho levels. Investigating this relationship could offer new insights into thrombocytosis pathogenesis. This study aimed to examine the relationship between serum Klotho levels and thrombocytosis in a U.S. cohort. We hypothesized that lower Klotho levels would be associated with an increased risk of thrombocytosis, potentially providing a novel perspective on thrombocytosis regulation. We conducted a cross-sectional analysis of data from 12,700 participants in the NHANES 2007-2016 cohort. Multivariate logistic regression models were used to assess the association between serum Klotho levels and thrombocytosis, adjusting for relevant covariates. Of the 12,700 participants, 86 had thrombocytosis. The thrombocytosis group had significantly lower mean serum Klotho levels compared to the non-thrombocytosis group (p < 0.01). After adjusting for confounders, an inverse association between serum Klotho levels and thrombocytosis was observed (odds ratio 0.89, 95% CI 0.82-0.97, p = 0.007). Compared to the lowest Klotho quartile (≤ 700.7 pg/ml), the adjusted odds ratios for thrombocytosis in the second (700.8-915.3 pg/ml) and third (≥ 915.4 pg/ml) quartiles were 0.6 (95% CI: 0.36-1.01, p = 0.055) and 0.49 (95% CI: 0.29-0.84, p = 0.01), respectively. Our findings suggest an inverse correlation between serum Klotho levels and thrombocytosis in adults aged 40 and older. These results highlight the potential role of Klotho in thrombocytosis regulation, and future longitudinal studies are needed to establish causality and explore the underlying mechanisms.
klotho是一种主要在肾脏和大脑中表达的蛋白质，在衰老、血管健康和各种代谢过程中起关键作用。血清klotho水平降低与多种慢性疾病相关，包括心血管疾病、糖尿病和肾脏疾病。尽管klotho在血小板调节中的作用仍未得到充分研究，但血小板增多症可能受klotho水平影响。研究这种关系可能为血小板增多症的发病机制提供新的见解。本研究旨在调查美国队列中血清klotho水平与血小板增多症之间的关系。我们假设较低的klotho水平与血小板增多症风险增加相关，这可能为血小板增多症的调节提供新的视角。我们对2007 - 2016年美国国家健康与营养检查调查（NHANES）队列中12,700名参与者的数据进行了横断面分析。使用多变量逻辑回归模型评估血清klotho水平与血小板增多症之间的关联，并对相关协变量进行调整。在12,700名参与者中，86人患有血小板增多症。与非血小板增多症组相比，血小板增多症组的平均血清klotho水平显著降低（p < 0.01）。在调整混杂因素后，观察到血清klotho水平与血小板增多症之间存在负相关（优势比0.89，95%置信区间0.82 - 0.97，p = 0.007）。与最低klotho四分位数（≤ 700.7 pg/ml）相比，第二四分位数（700.8 - 915.3 pg/ml）和第三四分位数（≥ 915.4 pg/ml）中血小板增多症的调整优势比分别为0.6（95%置信区间：0.36 - 1.01，p = 0.055）和0.49（95%置信区间：0.29 - 0.84，p = 0.01）。我们的研究结果表明，40岁及以上成年人的血清klotho水平与血小板增多症之间存在负相关。这些结果突出了klotho在血小板增多症调节中的潜在作用，未来需要进行纵向研究以确定因果关系并探索潜在机制。
