成年人膳食锌摄入量与偏头痛：1999 - 2004年美国国家健康与营养检查调查的横断面分析

Dietary zinc intake and migraine in adults: a cross-sectional analysis of the National Health and Nutrition Examination Survey 1999-2004.

作者信息

Liu Huanxian, Wang Qi, Dong Zhao, Yu Shengyuan

机构信息

Department of Neurology, the First Medical Center, Chinese PLA General Hospital, Beijing, China.

International Headache Center, Chinese PLA General Hospital, Beijing, China.

出版信息

Headache. 2023 Jan;63(1):127-135. doi: 10.1111/head.14431. Epub 2023 Jan 1.

DOI:10.1111/head.14431

PMID:36588459

Abstract

OBJECTIVE

The study examined the relationship between dietary zinc intake and migraine.

BACKGROUND

Neuroinflammatory and oxidative stress are involved in the pathogenesis of migraine. Little is known about the effects of zinc, an anti-inflammatory and antioxidant trace element, on migraine.

METHODS

The US National Health and Nutrition Examination Survey data from 1999 to 2004 were analyzed for this cross-sectional study. Participants who had severe headache or migraine were classified as having migraine. Dietary zinc intake was evaluated using the 24 h dietary recall system.

RESULTS

A total of 11,088 participants were included, of whom, 20.2% (2236/11,088) reported having migraine disease. Compared to the lowest dietary zinc intake quintile (Q1, ≤5.9 mg/day), the adjusted odds ratios for migraine in Q2 (6.0-8.4 mg/day), Q3 (8.5-11.2 mg/day), Q4 (11.3-15.7 mg/day), and Q5 (≥15.8 mg/day) were 0.73 (95% confidence interval [CI]: 0.61-0.88, p = 0.004), 0.71 (95% CI: 0.56-0.91, p = 0.013), 0.71 (95% CI: 0.57-0.90, p = 0.008), and 0.70 (95% CI: 0.52-0.94, p = 0.029), respectively. Sensitivity analysis of zinc supplementation survey participants also showed an association between dietary zinc intake and migraine. Compared to the lowest total zinc intake quintile (Q1: 0.5-9.6 mg/day), the adjusted odds ratios for migraine in Q3 (19.3-24.3 mg/day) and Q4 (24.4-32.5 mg/day) were 0.62 (95% CI: 0.46-0.83, p = 0.019) and 0.67 (95% CI: 0.49-0.91, p = 0.045), respectively.

CONCLUSIONS

Our findings indicate an inverse association between dietary zinc intake and migraine in adult Americans.

摘要

目的

本研究探讨膳食锌摄入量与偏头痛之间的关系。

背景

神经炎症和氧化应激参与偏头痛的发病机制。锌作为一种具有抗炎和抗氧化作用的微量元素，其对偏头痛的影响鲜为人知。

方法

本横断面研究分析了1999年至2004年美国国家健康与营养检查调查的数据。有严重头痛或偏头痛的参与者被归类为患有偏头痛。使用24小时膳食回忆系统评估膳食锌摄入量。

结果

共纳入11088名参与者，其中20.2%（2236/11088）报告患有偏头痛疾病。与膳食锌摄入量最低的五分位数（Q1，≤5.9毫克/天）相比，Q2（6.0 - 8.4毫克/天）、Q3（8.5 - 11.2毫克/天）、Q4（11.3 - 15.7毫克/天）和Q5（≥15.8毫克/天）中偏头痛的调整优势比分别为0.73（95%置信区间[CI]：0.61 - 0.88，p = 0.004）、0.71（95%CI：0.56 - 0.91，p = 0.013）、0.71（95%CI：0.57 - 0.90，p = 0.008）和0.70（95%CI：0.52 - 0.94，p = 0.029）。锌补充剂调查参与者的敏感性分析也显示膳食锌摄入量与偏头痛之间存在关联。与总锌摄入量最低的五分位数（Q1：0.5 - 9.6毫克/天）相比，Q3（19.3 - 24.3毫克/天）和Q4（24.4 - 32.5毫克/天）中偏头痛的调整优势比分别为0.62（95%CI：0.46 - 0.83，p = 0.019）和0.67（95%CI：0.49 - 0.91，p = 0.045）。