Zyuz'kov G N, Zhdanov V V, Miroshnichenko L A, Polyakova T Yu, Simanina E V, Chaykovskyi A V, Agafonov V I
Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
Bull Exp Biol Med. 2025 Feb;178(4):529-534. doi: 10.1007/s10517-025-06368-0. Epub 2025 Mar 29.
We studied the psychopharmacological effects of a NF-κB inhibitor, a stimulator of the functions of progenitor cells of the nervous tissue, under conditions of modeled ethanol-induced encephalopathy. The pharmacological agent improved indicators of the orientation and exploratory behavior and reproducibility of the conditioned passive avoidance reflex in experimental animals. These effects developed against the background of a significant increase in the content and proliferative activity of neural stem cells in the subventricular zone of the brain and intensification of their specialization. The results indicate the prospects of developing fundamentally new agents with regenerative activity based on NF-κB blockers for the treatment of alcoholic encephalopathy.
我们研究了一种NF-κB抑制剂（一种神经组织祖细胞功能刺激剂）在模拟乙醇诱导性脑病条件下的精神药理作用。该药物改善了实验动物的定向和探索行为指标以及条件性被动回避反射的再现性。这些作用是在脑室内侧区神经干细胞含量和增殖活性显著增加以及其特化强化的背景下产生的。结果表明，基于NF-κB阻滞剂开发具有再生活性的全新药物用于治疗酒精性脑病具有前景。
