Zhang Ziyi, Gao Xiaopeng, Liu Shiwei, Wang Qingshuai, Wang Yingjie, Hou Shuai, Wang Jun, Zhang Yimin
Department of Joint Surgery, Weifang People's Hospital, Shandong Second Medical University, Kuiwen District, Weifang, 261000, Shandong, China.
Emergency Department, Affiliated Hospital of Shandong Second Medical University, Weifang, Shandong, China.
Sci Rep. 2025 Mar 28;15(1):10736. doi: 10.1038/s41598-025-92150-1.
Rheumatoid arthritis (RA) is a global epidemic. We conducted a cross-sectional study using the Global Burden of Disease (GBD) 2021 dataset to examine RA trends in patients aged 20-54 years worldwide. Key outcomes included incidence, mortality, and disability-adjusted life years (DALYs), as well as trends over time, stratifying by region, country, age, sex, and Sociodemographic Index (SDI). We also assessed the contribution of smoking to RA-related mortality and DALYs. Over the past 32 years, the global RA-related incidence rate increased from 11.66 (95% UI 9.60-13.94) to 13.48 (95% UI 11.08-16.06) per 100,000 population. RA-related DALYs rate increased from 26.37 (95% UI 18.43-36.99) to 30.71 (95% UI 20.82-44.08) per 100,000 population, with females bearing a higher burden. And the RA-related mortality rate decreased from 0.09 (95% UI 0.08-0.1) to 0.06 (95% UI 0.05-0.07) per 100,000 population. Regional disparities were evident, with lower SDI regions experiencing the larger change. Smoking remained a significant risk factor, accounting for 9.01% of RA-related mortality in 2021. Overall, we highlighted the rising global burden of RA, particularly among females and in lower SDI regions, emphasizing disparities in healthcare resources, prevention, and early diagnosis.
类风湿关节炎（RA）是一种全球性疾病。我们使用全球疾病负担（GBD）2021数据集进行了一项横断面研究，以调查全球20至54岁患者的RA趋势。主要结果包括发病率、死亡率和伤残调整生命年（DALY），以及随时间的趋势，并按地区、国家、年龄、性别和社会人口指数（SDI）进行分层。我们还评估了吸烟对RA相关死亡率和DALY的影响。在过去32年中，全球RA相关发病率从每10万人11.66（95%UI 9.60 - 13.94）增至13.48（95%UI 11.08 - 16.06）。RA相关DALY率从每10万人26.37（95%UI 18.43 - 36.99）增至30.71（95%UI 20.82 - 44.08），女性负担更重。RA相关死亡率从每10万人0.09（95%UI 0.08 - 0.1）降至0.06（95%UI 0.05 - 0.07）。地区差异明显，SDI较低的地区变化更大。吸烟仍是一个重要风险因素，在2021年占RA相关死亡率的9.01%。总体而言，我们强调了全球RA负担的上升，特别是在女性和SDI较低的地区，强调了医疗资源、预防和早期诊断方面的差异。
