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Regulation of NAD- and NADP-linked isocitrate dehydrogenase by thyroxine in the brain and liver of female rats of various ages.

作者信息

Yadav R N

出版信息

Biochem Med. 1985 Jun;33(3):312-9. doi: 10.1016/0006-2944(85)90005-5.

DOI:10.1016/0006-2944(85)90005-5
PMID:4015631
Abstract

The specific activity of NAD- and NADP-linked isocitrate dehydrogenase and their regulation by thyroxine in the brain and liver of female rats of various ages were studied with the ultimate goal of better understanding the decreased physiological functioning of the brain and liver during old age. Both thyroidectomy and thyroxine treatment have differential age-dependent effects on the activities of these enzymes in both tissues. The activity of NAD-ICDH decreases whereas both cytoplasmic and mitochondrial NADP-ICDH increase simultaneously following thyroidectomy. Thyroxine administration induces NAD-ICDH and depresses NADP-ICDH. The degree of induction and/or repression is lowest in old rats. These effects of thyroxine are actinomycin D sensitive in both the tissues of rats.

摘要

相似文献

1
Regulation of NAD- and NADP-linked isocitrate dehydrogenase by thyroxine in the brain and liver of female rats of various ages.
Biochem Med. 1985 Jun;33(3):312-9. doi: 10.1016/0006-2944(85)90005-5.
2
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[Participation of thyroxine in the regulation of the rate of isocitrate dehydrogenase reactions in the brain and liver].
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Folia Med (Plovdiv). 1978;20(3):5-10.

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