Enhancement of NAD-linked isocitrate dehydrogenase activity in rat liver by clofibrate feeding.
作者信息
Schön H J, Kremser K, Prager C, Kramar R
机构信息
Department of Medical Chemistry, University of Vienna, Austria.
出版信息
Biochem Pharmacol. 1991 Jun 1;41(11):1773-5. doi: 10.1016/0006-2952(91)90183-6.
PMID:2043166
Abstract
After feeding rats for 3 weeks with clofibrate specific activities of the liver mitochondrial enzymes glycerol-3-phosphate dehydrogenase (G3PDH) and NAD-linked isocitrate dehydrogenase (NAD-ICDH) were found to be increased in a large particle fraction 6-fold and 1.6-fold, respectively, whereas the activity of NADP-linked isocitrate dehydrogenase (NADP-ICDH) remained unchanged. Possibly these effects contribute to the hypolipidemic action of clofibrate.
摘要
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