Peto Maximus V, Floyd Anthony J, Zealley Ben, de Grey Aubrey D N J
Long Life Labs, LLC, Buffalo, WY 82834, USA.
Longevity Escape Velocity (LEV) Foundation, San Francisco, CA 94107, USA.
Aging (Albany NY). 2025 Mar 27;17(3):851-862. doi: 10.18632/aging.206228.
Numerous studies have investigated the effects of various interventions on the lifespans of mice and rats. The design of future rodent lifespan extension experiments might consider experimental parameters used in earlier investigations, but finding and reviewing all previous experiments requires a substantial resource investment. Additionally, when studied collectively, the results of previous investigations might suggest fundamental mechanisms causing age-related degeneration. Here, we report our efforts to find and aggregate data from all research reports of lifespan extension in mice or rats, which we call the "Rodent Aging Interventions Database" (RAID). We identified studies for inclusion using complex PubMed queries and by nomination from our colleagues in the field. The relevant data from each study was manually extracted and recorded in a table. A publicly available, web-based software tool was then created to enable users to visualize and filter this data in a convenient manner. Our current dataset, covering publications up to October 2022, includes 121 unique studies reporting on 212 distinct intervention protocols that extended lifespan in mice or rats. We intend to periodically update our dataset as new rodent lifespan studies are reported. RAID is publicly available at https://levf.org/raid.
众多研究调查了各种干预措施对小鼠和大鼠寿命的影响。未来啮齿动物寿命延长实验的设计可能会考虑早期研究所使用的实验参数，但查找和回顾所有先前的实验需要大量资源投入。此外，当对先前的研究结果进行综合分析时，可能会揭示导致与年龄相关衰退的基本机制。在此，我们报告了我们为查找和汇总小鼠或大鼠寿命延长的所有研究报告中的数据所做的努力，我们将其称为“啮齿动物衰老干预数据库”（RAID）。我们通过复杂的PubMed查询以及该领域同事的提名来确定纳入研究。从每项研究中手动提取相关数据并记录在表格中。随后创建了一个基于网络的公开可用软件工具，以便用户能够以方便的方式可视化和筛选这些数据。我们目前的数据集涵盖截至2022年10月的出版物，包括121项独特的研究，报告了212种不同的延长小鼠或大鼠寿命的干预方案。我们打算随着新的啮齿动物寿命研究报告定期更新我们的数据集。RAID可在https://levf.org/raid上公开获取。
