Integrative Genomics of Ageing Group, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool L7 8TX, UK.
Computational Biology of Aging Group, Institute of Biochemistry, Romanian Academy, Bucharest 060031, Romania.
Nucleic Acids Res. 2018 Jan 4;46(D1):D1083-D1090. doi: 10.1093/nar/gkx1042.
In spite of a growing body of research and data, human ageing remains a poorly understood process. Over 10 years ago we developed the Human Ageing Genomic Resources (HAGR), a collection of databases and tools for studying the biology and genetics of ageing. Here, we present HAGR's main functionalities, highlighting new additions and improvements. HAGR consists of six core databases: (i) the GenAge database of ageing-related genes, in turn composed of a dataset of >300 human ageing-related genes and a dataset with >2000 genes associated with ageing or longevity in model organisms; (ii) the AnAge database of animal ageing and longevity, featuring >4000 species; (iii) the GenDR database with >200 genes associated with the life-extending effects of dietary restriction; (iv) the LongevityMap database of human genetic association studies of longevity with >500 entries; (v) the DrugAge database with >400 ageing or longevity-associated drugs or compounds; (vi) the CellAge database with >200 genes associated with cell senescence. All our databases are manually curated by experts and regularly updated to ensure a high quality data. Cross-links across our databases and to external resources help researchers locate and integrate relevant information. HAGR is freely available online (http://genomics.senescence.info/).
尽管有越来越多的研究和数据，但人类衰老仍然是一个理解不足的过程。10 多年前，我们开发了人类衰老基因组资源（HAGR），这是一个用于研究衰老生物学和遗传学的数据库和工具集合。在这里，我们介绍了 HAGR 的主要功能，重点介绍了新的添加和改进。HAGR 由六个核心数据库组成：（i）与衰老相关的基因 GenAge 数据库，其中包含>300 个人类衰老相关基因的数据集和>2000 个与模型生物衰老或长寿相关的基因数据集；（ii）动物衰老和长寿的 AnAge 数据库，包含>4000 个物种；（iii）与饮食限制延长寿命相关的>200 个基因的 GenDR 数据库；（iv）与长寿相关的人类遗传关联研究的 LongevityMap 数据库，有>500 项研究；（v）与衰老或长寿相关的>400 种药物或化合物的 DrugAge 数据库；（vi）与细胞衰老相关的>200 个基因的 CellAge 数据库。我们所有的数据库都由专家手动整理，并定期更新，以确保高质量的数据。数据库之间以及与外部资源的交叉链接有助于研究人员找到并整合相关信息。HAGR 可免费在线获取（http://genomics.senescence.info/）。
