CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China.
University of Chinese Academy of Sciences, Beijing 100049, China.
Nucleic Acids Res. 2024 Jan 5;52(D1):D909-D918. doi: 10.1093/nar/gkad880.
Diverse individuals age at different rates and display variable susceptibilities to tissue aging, functional decline and aging-related diseases. Centenarians, exemplifying extreme longevity, serve as models for healthy aging. The field of human aging and longevity research is rapidly advancing, garnering significant attention and accumulating substantial data in recent years. Omics technologies, encompassing phenomics, genomics, transcriptomics, proteomics, metabolomics and microbiomics, have provided multidimensional insights and revolutionized cohort-based investigations into human aging and longevity. Accumulated data, covering diverse cells, tissues and cohorts across the lifespan necessitates the establishment of an open and integrated database. Addressing this, we established the Human Aging and Longevity Landscape (HALL), a comprehensive multi-omics repository encompassing a diverse spectrum of human cohorts, spanning from young adults to centenarians. The core objective of HALL is to foster healthy aging by offering an extensive repository of information on biomarkers that gauge the trajectory of human aging. Moreover, the database facilitates the development of diagnostic tools for aging-related conditions and empowers targeted interventions to enhance longevity. HALL is publicly available at https://ngdc.cncb.ac.cn/hall/index.
不同的个体衰老速度不同，对组织衰老、功能下降和与衰老相关疾病的易感性也不同。百岁老人是长寿的典范，他们为健康衰老提供了模型。人类衰老和长寿研究领域正在迅速发展，近年来受到了极大的关注，并积累了大量的数据。组学技术，包括表型组学、基因组学、转录组学、蛋白质组学、代谢组学和微生物组学，提供了多维的见解，并彻底改变了基于队列的人类衰老和长寿研究。在整个生命周期中，涵盖不同细胞、组织和队列的积累数据需要建立一个开放和集成的数据库。为了解决这个问题，我们建立了人类衰老和长寿全景数据库（HALL），这是一个综合性的多组学资源库，涵盖了从年轻人到百岁老人的各种人类队列。HALL 的核心目标是通过提供广泛的生物标志物信息库来促进健康衰老，这些标志物可以衡量人类衰老的轨迹。此外，该数据库还为与衰老相关疾病的诊断工具的开发提供了便利，并为增强寿命的靶向干预提供了支持。HALL 可在 https://ngdc.cncb.ac.cn/hall/index 上公开获取。
