Rowe E S
Alcohol. 1985 Jan-Feb;2(1):173-6. doi: 10.1016/0741-8329(85)90038-2.
We have been systematically investigating the physical interactions of alcohols with synthetic lipids in order to elucidate the mechanisms of alcohol intoxication. It has previously been shown that the effects of ethanol on the phase transition temperatures of saturated chain phosphatidylcholines (PC's) are biphasic [11]. The secondary high concentration effect has recently been shown to be due to a transition to a new completely interdigitated state [16]. In the present report we have investigated the influence of the chain length of the alcohol on the induction of this interdigitated state. We demonstrate that all three alcohols have a biphasic effect on the transition temperature of PC, and the comparison of the concentration dependencies of this effect for the three alcohols provides some insight into the possible mechanism of the transition. The potential biological importance of this secondary alcohol-membrane interaction is discussed.
为了阐明酒精中毒的机制，我们一直在系统地研究醇类与合成脂质的物理相互作用。先前已经表明，乙醇对饱和链磷脂酰胆碱（PC）相变温度的影响是双相的[11]。最近已表明，高浓度时的二次效应是由于转变为一种全新的完全交错状态[16]。在本报告中，我们研究了醇类链长对这种交错状态诱导的影响。我们证明，所有三种醇类对PC的转变温度都有双相效应，并且比较这三种醇类这种效应的浓度依赖性，为转变的可能机制提供了一些见解。讨论了这种醇类与膜相互作用的潜在生物学重要性。
