Saccaro Luigi F, Delavari Farnaz, Meuleman Ben, Perroud Nader, Van De Ville Dimitri, Piguet Camille
Psychiatry Department, Faculty of Medicine, University of Geneva, Geneva, Switzerland; Psychiatry Department, Geneva University Hospital, Geneva, Switzerland; Department of Radiology and Medical Informatics, Faculty of Medicine, University of Geneva, Geneva, Switzerland; Medical Image Processing Laboratory, Neuro-X Institute, École Polytechnique Fédérale de Lausanne, Geneva, Switzerland.
Medical Image Processing Laboratory, Neuro-X Institute, École Polytechnique Fédérale de Lausanne, Geneva, Switzerland; Developmental Imaging and Psychopathology Laboratory, University of Geneva School of Medicine, Geneva, Switzerland.
Biol Psychiatry Cogn Neurosci Neuroimaging. 2025 Mar 28. doi: 10.1016/j.bpsc.2025.03.007.
Emotion dysregulation (ED) is a key transdiagnostic symptom in several psychiatric disorders such as borderline personality disorder, bipolar disorder, and attention-deficit/hyperactivity disorder. These disorders, defined herein as ED disorders (EDDs), share similarities in symptoms, comorbidity, and heritability, emphasizing the importance of a transdiagnostic approach to identify markers of vulnerability to EDDs in high-risk populations, such as the offspring of patients with an EDD (EDDoff). The hippocampus, central to ED, exhibits alterations across EDDs.
We used a state-of-the-art approach (micro-coactivation patterns [μCAPs]) to study the transdiagnostic dynamic functional connectivity (dFC) of hippocampal subregions from resting-state functional magnetic resonance imaging of 201 participants (74 patients with an EDD, 57 EDDoff, 70 healthy control participants). μCAPs provide a data-driven differentiation within the seed region.
dFC between the sensorimotor network (SMN) and the hippocampal body was lower in patients with EDDs (false discovery rate [FDR]-corrected p = .0002) and in EDDoff (p = .01) than in control participants, with EDDoff displaying an intermediate pattern between patients with EDDs and control participants. dFC between the limbic network (LN) and the hippocampal head was higher in patients with EDDs than in control participants (p = .01) and EDDoff (p = .01). A negative correlation was found between ED and the SMN (p = .01), indicating increasing ED with decreasing SMN dFC with the hippocampus.
Increased dFC between the hippocampal head and the LN, at the expense of the SMN, may represent a marker of disease in patients with EDDs. Lower dFC between the SMN and the hippocampal body may represent a marker of vulnerability to EDDs in EDDoff that is correlated with ED. Such a transdiagnostic construct represents a clinically relevant target for early interventions aimed at reducing vulnerability to EDDs in high-risk populations.
情绪调节障碍（ED）是几种精神疾病的关键跨诊断症状，如边缘性人格障碍、双相情感障碍和注意力缺陷多动障碍。本文将这些疾病定义为ED障碍（EDDs），它们在症状、共病性和遗传力方面具有相似性，这凸显了采用跨诊断方法来识别高危人群（如ED障碍患者的后代[EDDoff]）中EDD易感性标志物的重要性。海马体是ED的核心，在各种EDD中均表现出改变。
我们采用一种先进的方法（微共激活模式[μCAPs]），通过静息态功能磁共振成像研究了201名参与者（74名EDD患者、57名EDDoff、70名健康对照参与者）海马亚区的跨诊断动态功能连接（dFC）。μCAPs可在种子区域内进行数据驱动的区分。
与对照参与者相比，EDD患者（错误发现率[FDR]校正后p = 0.0002）和EDDoff（p = 0.01）的感觉运动网络（SMN）与海马体之间的dFC较低，EDDoff表现出介于EDD患者和对照参与者之间的中间模式。与对照参与者（p = 0.01）和EDDoff（p = 0.01）相比，EDD患者的边缘网络（LN）与海马头部之间的dFC较高。在ED与SMN之间发现负相关（p = 0.01），表明随着SMN与海马体之间dFC的降低，ED增加。
以牺牲SMN为代价，海马头部与LN之间dFC的增加可能代表EDD患者的疾病标志物。SMN与海马体之间较低的dFC可能代表EDDoff中EDD易感性的标志物，且与ED相关。这种跨诊断结构代表了针对高危人群旨在降低EDD易感性早期间干预的临床相关靶点。
