Wang Yunping, Wang Lintai, Luo Liping, Ning Fangjian, Li Jinwang
Key Laboratory of Geriatric Nutrition and Health of Ministry of Education, School of Food and Health, Beijing Technology and Business University, Beijing 100048, China.
J Agric Food Chem. 2025 Apr 9;73(14):8113-8128. doi: 10.1021/acs.jafc.5c01483. Epub 2025 Mar 30.
Pesticides are crucial for agricultural production, but their excessive use has become a significant pollution source, leading to increased pesticide residues in the environment and food and posing a threat to human health. pesticide toxicology research aims to protect humans with detection technology playing a key role. Spatial information plays a crucial role in pesticide toxicity research. However, current technologies cannot simultaneously analyze the content and spatial information on pesticides . Mass spectrometry imaging (MSI) technology can address this limitation by simultaneously analyzing the content and spatial distribution of chemicals with high sensitivity and efficiency, aiding in the discovery of toxic biomarkers and mechanisms. Nevertheless, the limited application of MSI pesticide toxicology research hinders the accuracy of such research. Therefore, MSI should be promoted to enhance the accuracy of pesticide toxicology research.
农药对农业生产至关重要，但其过度使用已成为一个重要的污染源，导致环境和食品中的农药残留增加，对人类健康构成威胁。农药毒理学研究旨在通过发挥关键作用的检测技术来保护人类。空间信息在农药毒性研究中起着至关重要的作用。然而，目前的技术无法同时分析农药的含量和空间信息。质谱成像（MSI）技术可以通过高灵敏度和高效率地同时分析化学物质的含量和空间分布来解决这一局限性，有助于发现毒性生物标志物和作用机制。尽管如此，MSI在农药毒理学研究中的应用有限，阻碍了此类研究的准确性。因此，应推广MSI以提高农药毒理学研究的准确性。
