自闭症谱系障碍与维生素E的饮食摄入

Autism Spectrum Disorder and Dietary Intake of Vitamin E.

作者信息

Mobarakeh Khadijeh Abbasi, Mahmoudi Zahra, Mousavi Zahra, Ataei Kachooei Masoomeh, Adabi Somayyeh Bararnia, Bahoo Sele Nabi Samira, Moradi Mahdi, Saeedirad Zahra, Mohammadi Saeideh, Yazdi Seyed Ali Namakian, Alhouei Barbod, Ashouri Mirsadeghi Narjes, Doaei Saeid, Gholamalizadeh Maryam

机构信息

Department of Community Nutrition, Nutrition and Food Security Research Center, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.

School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.

出版信息

Neuropsychopharmacol Rep. 2025 Jun;45(2):e70011. doi: 10.1002/npr2.70011.

DOI:10.1002/npr2.70011

PMID:40159405

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11955277/

Abstract

BACKGROUND

Autism Spectrum Disorder (ASD) is a complicated condition that affects brain development, possibly caused by genetics and environmental factors. Individuals with ASD manifest a lack of balance between pathways that cause oxidative stress and levels of anti-oxidant agents. However, the association between ASD and dietary intake of antioxidants, such as vitamin E, is not yet clear.

OBJECTIVES

This study aimed to compare the dietary vitamin E intake in children with ASD and typically developing (TD) children.

METHODS

Totally, 110 individuals with ASD from 5 to 15 years were selected as the case group and 110 TD children of the same age group were selected as the control group. The (GARS 2) was used to confirm the participants' ASD diagnoses. The food frequency questionnaire (FFQ) was used for collecting the required information on the child's diet. The Nutritionist IV software was used to evaluate the intake of different types of vitamin E.

RESULT

A significantly lower intake of dietary vitamin E was observed in individuals with ASD relative to the control group (15.66 ± 12.72 vs. 28.60 ± 10.85 mg/day, p > 0.001). After adjusting for confounders such as age, gender, mother's age, Body Mass Index (BMI), and diet, decreased vitamin E intake was associated with an increased risk of developing ASD (OR = 0.90, 95% CI: 0.85-0.94, p < 0.001).

CONCLUSION

An increased intake of vitamin E may be associated with a decreased risk of ASD. Further research is required to confirm this finding.

摘要

背景

自闭症谱系障碍（ASD）是一种影响大脑发育的复杂病症，可能由遗传和环境因素引起。患有ASD的个体在导致氧化应激的通路和抗氧化剂水平之间表现出失衡。然而，ASD与抗氧化剂（如维生素E）的饮食摄入量之间的关联尚不清楚。

目的

本研究旨在比较ASD儿童和发育正常（TD）儿童的膳食维生素E摄入量。

方法

总共选取110名5至15岁的ASD个体作为病例组，选取110名同年龄组的TD儿童作为对照组。使用（GARS 2）来确认参与者的ASD诊断。食物频率问卷（FFQ）用于收集有关儿童饮食的所需信息。使用Nutritionist IV软件评估不同类型维生素E的摄入量。

结果

与对照组相比，ASD个体的膳食维生素E摄入量显著较低（15.66±12.72 vs. 28.60±10.85毫克/天，p>0.001）。在调整年龄、性别、母亲年龄、体重指数（BMI）和饮食等混杂因素后，维生素E摄入量降低与患ASD的风险增加相关（OR = 0.90，95% CI：0.85 - 0.94，p < 0.001）。