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Sensitivity to fetal hormone GDF15 drives maternal risk of nausea and vomiting during pregnancy.

作者信息

Deng Cechuan, Wang Yu, Xu Jinfeng, Ding Yang-Nan, Tang Xiaoqiang

机构信息

Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, National Health Commission Key Laboratory of Chronobiology, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, China.

Department of Medical Genetics/Prenatal Diagnostic Center, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, China.

出版信息

Chin Med J (Engl). 2025 May 20;138(10):1245-1247. doi: 10.1097/CM9.0000000000003481. Epub 2025 Mar 31.

DOI:10.1097/CM9.0000000000003481
PMID:40159877
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12091625/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a93/12091625/e8123c0ac5cf/cm9-138-1245-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a93/12091625/e8123c0ac5cf/cm9-138-1245-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a93/12091625/e8123c0ac5cf/cm9-138-1245-g001.jpg

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Sensitivity to fetal hormone GDF15 drives maternal risk of nausea and vomiting during pregnancy.对胎儿激素生长分化因子15（GDF15）的敏感性会增加孕妇恶心和呕吐的风险。
Chin Med J (Engl). 2025 May 20;138(10):1245-1247. doi: 10.1097/CM9.0000000000003481. Epub 2025 Mar 31.
2
GDF15 linked to maternal risk of nausea and vomiting during pregnancy.GDF15 与孕妇恶心和呕吐的母体风险相关。
Nature. 2024 Jan;625(7996):760-767. doi: 10.1038/s41586-023-06921-9. Epub 2023 Dec 13.
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Fetally-encoded GDF15 and maternal GDF15 sensitivity are major determinants of nausea and vomiting in human pregnancy.胎儿编码的生长分化因子15（GDF15）和母体对GDF15的敏感性是人类妊娠期间恶心和呕吐的主要决定因素。
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Associations of vomiting and antiemetic use in pregnancy with levels of circulating GDF15 early in the second trimester: A nested case-control study.孕早期呕吐及使用止吐药与孕中期早期循环GDF15水平的关联：一项巢式病例对照研究
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Evol Med Public Health. 2024 Apr 23;12(1):75-81. doi: 10.1093/emph/eoae008. eCollection 2024.
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Multi-ancestry GWAS of severe pregnancy nausea and vomiting identifies risk loci associated with appetite, insulin signaling, and brain plasticity.严重妊娠恶心和呕吐的多血统全基因组关联研究确定了与食欲、胰岛素信号传导和大脑可塑性相关的风险位点。
medRxiv. 2024 Nov 20:2024.11.19.24317559. doi: 10.1101/2024.11.19.24317559.
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Analysis of GDF15 and IGFBP7 in Hyperemesis Gravidarum Support Causality.妊娠剧吐中GDF15和IGFBP7的分析支持因果关系。
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Evidence GDF15 Plays a Role in Familial and Recurrent Hyperemesis Gravidarum.证据表明生长分化因子15在家族性及复发性妊娠剧吐中起作用。
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Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum.胎盘和食欲基因 GDF15 和 IGFBP7 与妊娠剧吐有关。
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本文引用的文献

1
Hyperemesis gravidarum theories dispelled by recent research: a paradigm change for better care and outcomes.近期研究消除了妊娠剧吐的理论：更好的护理和结果的范式转变。
Trends Mol Med. 2024 Jun;30(6):530-540. doi: 10.1016/j.molmed.2024.04.006. Epub 2024 May 22.
2
GDF15 linked to maternal risk of nausea and vomiting during pregnancy.GDF15 与孕妇恶心和呕吐的母体风险相关。
Nature. 2024 Jan;625(7996):760-767. doi: 10.1038/s41586-023-06921-9. Epub 2023 Dec 13.
3
GDF15 deficiency hinders human trophoblast invasion to mediate pregnancy loss through downregulating Smad1/5 phosphorylation.
生长分化因子15（GDF15）缺乏通过下调Smad1/5磷酸化来阻碍人滋养层细胞侵袭，从而介导妊娠丢失。
iScience. 2023 Sep 13;26(10):107902. doi: 10.1016/j.isci.2023.107902. eCollection 2023 Oct 20.
4
GDF15: emerging biology and therapeutic applications for obesity and cardiometabolic disease.生长分化因子15：肥胖和心血管代谢疾病的新兴生物学及治疗应用
Nat Rev Endocrinol. 2021 Oct;17(10):592-607. doi: 10.1038/s41574-021-00529-7. Epub 2021 Aug 11.
5
Nausea and vomiting of pregnancy and hyperemesis gravidarum.妊娠恶心和呕吐及妊娠剧吐。
Nat Rev Dis Primers. 2019 Sep 12;5(1):62. doi: 10.1038/s41572-019-0110-3.
6
Associations of vomiting and antiemetic use in pregnancy with levels of circulating GDF15 early in the second trimester: A nested case-control study.孕早期呕吐及使用止吐药与孕中期早期循环GDF15水平的关联：一项巢式病例对照研究
Wellcome Open Res. 2018 Sep 21;3:123. doi: 10.12688/wellcomeopenres.14818.1. eCollection 2018.
7
Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum.胎盘和食欲基因 GDF15 和 IGFBP7 与妊娠剧吐有关。
Nat Commun. 2018 Mar 21;9(1):1178. doi: 10.1038/s41467-018-03258-0.