Bhuya M S I, Saiduzzaman M, Linckon K, Moniruzzaman A H M, Hossain M S, Rahman M R N, Haque M A, Rana M M, Losy S A, Khaer M A, Haque M A, Hossain M F, Islam M S, Islam M F, Bhattacharjee M
Dr Md Shahidul Islam Bhuya, Emergency Medical Officer, Mymensingh Medical College Hospital (MMCH), Mymensingh, Bangladesh; E-mail:
Mymensingh Med J. 2025 Apr;34(2):312-318.
Migraine is one of the commonest primary headache disorders associated with significant morbidity as well as reduced quality of life. As low serum vitamin D level was found in association with various neurologic and non-neurologic disorders, it may be associated with migraine as well. This study was designed to determine the association between low serum vitamin D levels and migraine. This cross-sectional comparative study was conducted in the Department of Neurology, Mymensingh Medical College Hospital, Bangladesh from July 2019 to June 2021. Total 328 patients were selected based on inclusion and exclusion criteria following informed written consent and divided into two groups. One hundred and sixty-four (164) migraine patients were enrolled in migraine group and same number of age and gender-matched apparently healthy individuals were included in non-migraine group. Detailed history taking and clinical examinations were done and serum vitamin D level was measured in all participants. Demographic variables of both groups were calculated without any significant difference. The mean serum vitamin D level was measured 16.11±6.33 ng/ml in case group and 23.13±8.71 ng/ml in control group with a statistically significant difference (p<0.001). A significant difference was also found in relation to the frequency of migraine attacks (18.49±6.70 ng/ml with ≤3 episodes/month and 14.84±5.76 ng/ml with >3 episodes/month, p<0.001). Mean serum vitamin D was measured lower in moderate and severe disease (23.67±4.86 ng/ml in mild disease, 19.79±5.97 ng/ml in moderate disease,12.94±4.24 ng/ml in severe disease, p<0.001). No significant difference in serum vitamin D level was found in terms of presence or absence of aura. But serum vitamin D level was significantly lower in migraine patients having positive family history (p=0.002). Considering the above findings, it is evident that serum vitamin D level is most likely to be associated with migraine. Early detection of low serum vitamin D levels and measures to correct it may be an adjunctive management strategy in migraine.
偏头痛是最常见的原发性头痛疾病之一，会导致严重的发病率以及生活质量下降。由于血清维生素D水平低与各种神经和非神经疾病有关，它也可能与偏头痛有关。本研究旨在确定低血清维生素D水平与偏头痛之间的关联。这项横断面比较研究于2019年7月至2021年6月在孟加拉国迈门辛医学院医院神经内科进行。根据纳入和排除标准，在获得知情书面同意后，共选择了328名患者，并将其分为两组。164名偏头痛患者被纳入偏头痛组，相同数量的年龄和性别匹配的明显健康个体被纳入非偏头痛组。对所有参与者进行了详细的病史采集和临床检查，并测量了血清维生素D水平。两组的人口统计学变量计算结果无显著差异。病例组的平均血清维生素D水平为16.11±6.33 ng/ml，对照组为23.13±8.71 ng/ml，差异有统计学意义（p<0.001）。在偏头痛发作频率方面也发现了显著差异（每月发作≤3次时为18.49±6.70 ng/ml，每月发作>3次时为14.84±5.76 ng/ml，p<0.001）。中重度疾病患者的平均血清维生素D水平较低（轻度疾病为23.67±4.86 ng/ml，中度疾病为19.79±5.97 ng/ml，重度疾病为12.94±4.24 ng/ml，p<0.001）。在有无先兆方面，血清维生素D水平无显著差异。但有家族史的偏头痛患者血清维生素D水平显著较低（p=0.002）。考虑到上述发现，很明显血清维生素D水平很可能与偏头痛有关。早期发现低血清维生素D水平并采取措施加以纠正可能是偏头痛的一种辅助治疗策略。
